急性区域性隐匿性外层视网膜病变

Acute zonal occult outer retinopathy

急性区域性隐匿性外层视网膜病变(AZOOR)是获得性视网膜病变,多发生于健康年轻女性,以视力下降和视野缺损并伴有闪光为特征表现。检眼镜下可见视网膜正常或轻微异常,眼底可出现RPE萎缩,与白点综合征有许多相似之处。FFA与ICGA无特征性,但在鉴别诊断中有重要价值,可以排除其他视网膜脉络膜病变。AZOOR患者FAF表现复杂多样;OCT显示椭圆体带区域性异常;均伴有不同程度的视野缺损,视野缺损区域与OCT显示的椭圆体带损害部位相对应;ERG表现为视杆反应、最大反应、视锥反应及闪烁光反应不同程度的振幅降低及潜伏期延长。FAF、OCT、视野及ERG的特征性改变是诊断AZOOR的重要指标。AZOOR有一定自限性,目前尚无有效治疗方法。

Acute zonal occult outer retinopathy (AZOOR) is an acquired retinal diseases. The majority of patients who develop AZOOR are women characterized by an acute onset of visual blurred and scotoma with photopsias. The fundus examination is often normal or appeared mild abnormal. The RPE atrophy of fundus is similar with white syndrome. Although FFA and ICGA features are either unremarkable or unrelated to AZOOR, there are still important in differential diagnosis. The characteristic abnormalities appearance of FAF(complicated and varied), OCT (regional anomaly of ellipsoid zone), visual field (visual field defect) and ERG(decreased amplitude and prolonged latency of rod reaction, maximum reaction, cone reaction and scintillation reaction) are considered critical examinations to the diagnosis of AZOOR. Although there is no effective therapy for AZOOR, it has some self-limitation.