髓系肉瘤7例临床分析

Clinical analysis of seven cases of myeloid sarcoma

目的探讨髓系肉瘤的临床表现、病理特点、诊断及治疗方法,提高对髓系肉瘤的认识。方法对7例髓系肉瘤患者的临床资料、诊断及治疗进行回顾性分析。结果 7例髓系肉瘤患者中,男1例,女6例。大多数患者以无痛性局部肿块或肿块引起的局部压迫症状为首发表现,1例患者病变累及宫颈,以阴道出血为首发症状。病变部位广泛,共累及19个部位。免疫组化染色的阳性比例CD43为6/6,MPO为6/7,CD117为4/5,LCA为4/4,CD34为3/5,CD99为2/2;7例患者淋巴细胞标志物CD3和CD20均为阴性。结论髓系肉瘤是一种临床罕见的血液恶性肿瘤,早期诊断和积极治疗是改善预后的关键。目前常用的治疗手段包括全身化疗、手术切除、放疗及造血干细胞移植。

Objective To investigate the clinical manifestations, pathological features, diagnosis and treatment of myeloid sarcoma, and to improve the understanding of myeloid sarcoma. Methods The clinical data, diagnosis and treatment of 7 patients with myeloid sarcoma were retrospectively analyzed. Results Of the 7 patients with myeloid sarcoma, 1 was male and 6 were female. In most patients, the local compression symptoms caused by painless local masses or masses were the first manifestations. One patient had lesions involving the cervix and vaginal bleeding was the first symptom. The lesions were extensive with 19 sites involved. The positive proportion of immunohistochemical staining was 6/6 for CD43, 6/7 for MPO, 4/5 for CD117, 4/4 for LCA, 3/5 for CD34 and 2/2 for CD99. Lymphocyte markers CD3 and CD20 were negative in all 7 patients. Conclusions Myeloid sarcoma is a rare hematological malignancy. Early diagnosis and active treatment are the key to improve prognosis. Current treatments include systemic chemotherapy, surgical resection, radiation therapy, and hematopoietic stem cell transplantation.