术前外周血NLR和PLR检测对非小细胞肺癌患者预后的评估意义

Significance of preoperative peripheral blood NLR and PLR in the prognosis evaluation of patients with non-small cell lung cancer

目的探讨术前外周血中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值对非小细胞肺癌患者预后的评估价值。方法对80例非小细胞肺癌患者的临床资料进行回顾性分析,并电话随访5a统计生存率。采用Kaplan-Meier法进行生存分析,并绘制中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值的受试者工作曲线图区分高比值、低比值,采用Cox回归模型进行单因素和多因素预后分析。结果本组患者中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值的临界值分别为3.3和169,不同中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值患者的性别、吸烟史、肿瘤分期比较差异有统计学意义(P<0.05)。Kaplan-Meier分析结果显示,术前患者中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值越高其预后越差;Cox分析显示,中性粒细胞/淋巴细胞比值≥3.3是非小细胞肺癌患者总体生存率的独立危险因素(P<0.05)。结论术前炎症指标中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值对非小细胞肺癌患者预后的评估具有重要意义。

Objective To investigate the prognostic value of preoperative peripheral blood NLR and PLR in the prognosis of patients with non-small cell lung cancer.Methods Clinical data of 80 patients with NSCLC were retrospectively analyzed and telephone followed up for five years.Survival analysis using Kaplan-Meier method,the ROC curve of NLR and PLR was made to distinguish high ratio and low ratio.Univariate and multivariate prognostic analyses were performed using the Cox regression model.Results The critical values of NLR and PLR in this group were 3.3 and 169,respectively.There were significant differences in gender,smoking history and tumor stage between patients with different NLR and PLR(P<0.05).Kaplan-Meier analysis showed that the higher the NLR and PLR of the preoperative patients,the worse the prognosis;Cox analysis showed that NLR ratio ≥3.3 was an independent risk factor for overall survival in patients with non-small cell lung cancer(P<0.05).Conclusions Preoperative inflammatory markers NLR and PLR are important for the assessment of prognosis in patients with non-small cell lung cancer.