多潘立酮联合黛力新阿普唑仑治疗功能性消化不良对照研究

A comparative study of Deanxit combined with alprazolam in the treatment of functional dyspepsia

目的探讨多潘必酮联合黛力新、阿普唑仑治疗功能性消化不良的临床疗效及对患者情绪、胃肠功能和胃肠激素水平的影响。方法将92例功能性消化不良患者按入院顺序随机分为实验组和对照组,每组46例。两组均给予多潘立酮治疗,实验组在此基础上联合黛力新、阿普唑仑治疗。观察6周。比较两组临床疗效及治疗前后胃肠排空率、焦虑抑郁状态以及胃肠激素水平。结果实验组总有效率显著高于对照组(P<0.05)。治疗6周末,两组焦虑自评量表指数和抑郁自评量表指数均较治疗前显著下降(P<0.05或0.01),胃肠排空率及血清胃泌素、血浆胃动素、血浆神经肽水平均较治疗前显著升高(P<0.05或0.01),实验组显著优于对照组(P<0.05或0.01)。结论多潘立酮联合黛力新、阿普唑仑治疗功能性消化不良疗效显著,能明显改善患者的焦虑抑郁情绪、胃肠功能,提高胃肠激素水平。

Objective To investigate the curative effect of Deanxit combined with alprazolam in the treatment of functional dyspepsia(FD)and the influence on patient mood,gastrointestinal function and gastrointestinal hormone levels.Methods According to the order of admission,92 patients with FD were randomly divided into the experimental group and the control group with 46 patients in each group.The two groups were all treated with domperidone,on the basis of this,the experimental group added Deanxit combined with alprazolam.All patients were observed for 6 weeks.The clinical efficacy and the gastrointestinal emptying rate,anxiety and depression status and gastrointestinal hormone levels before and after treatment of the two groups were compared.Results The total effective rate of treatment in the experimental group was higher than that in the control group(P<0.05).After 6 weeks of treatment,the anxiety self-rating scale index and the self-rating depression index of the two groups were significantly lower than those before treatment(P<0.05 or 0.01).The gastrointestinal emptying rate and serum gastrin,plasma motilin and plasma neuropeptide levels were significantly higher than those before treatment(P<0.05 or 0.01).The experimental group was significantly better than the control group(P<0.05 or 0.01).Conclusion On the basis of domperidone treatment,Deanxit combined with alprazolam is effective in the treatment of FD.It can relieve anxiety and depression and improve the gastrointestinal function in patients.