低分子肝素钠联合复方丹参注射液对子痫前期患者β-hCG AFP及脂联素水平的影响

Effects of compound salvia miltiorrhiza injection combined with low molecular weight heparin anticoagulation on β-hCG,AFP and adiponectin levels in preeclampsia patients

目的探讨低分子肝素钠联合复方丹参注射液对子痫前期患者人绒毛膜促性腺激素、甲胎蛋白及脂联素水平的影响。方法将96例子痫前期患者按随机数字表法分为两组,每组48例。两组均给予低分子肝素钠抗凝治疗,观察组在此基础上联合复方丹参注射液治疗,观察5d。治疗前后测定并比较两组血压、人绒毛膜促性腺激素、甲胎蛋白及脂联素水平。结果治疗前两组各项指标比较差异无统计学意义(P>0.05);治疗后两组血压、人绒毛膜促性腺激素、甲胎蛋白水平均较治疗前显著降低(P<0.05),脂联素水平较治疗前显著升高(P<0.05),两组比较差异有统计学意义(P<0.05)。结论低分子肝素钠联合复方丹参注射液可有效降低子痫前期患者血压、人绒毛膜促性腺激素、甲胎蛋白水平,提高脂联素水平,改善患者的血管功能及其临床症状。

Objective To observe the effects of compound salvia miltiorrhiza injection combined with low molecular weight heparin anticoagulation on levels of human chorionic gonadotropin(β-hCG),alpha fetoprotein(AFP)and adiponectin(ADPN)in preeclampsia patients(PE).Methods 96 patients with PE were randomly divided into two groups,48 cases in each group.Both groups were given low molecular weight heparin anticoagulant therapy,the observation group received the treatment of compound Danshen injection on the basis of the control group,patients were observed for 5d.The blood pressure indexes,β-hCG,AFP and ADPN levels were compared between the two groups before and after treatment.Results There was no significant difference in each index between the two groups before treatment(P>0.05).After treatment,blood pressure indexes,β-hCG and AFP levels of the two groups decreased(P<0.05).The levels of ADPN increased in both groups(P<0.05),the difference between the two groups was statistically significant(P<0.05).Conclusion Compound Danshen injection combined with low molecular weight heparin anticoagulation can effectively reduce blood pressure,β-hCG and AFP levels in PE patients,increase ADPN levels,and improve vascular function and clinical symptoms of patients.