北京大学肿瘤医院门诊患者2008—2017年强阿片类药物使用分析

Use analysis of strong opioid drugs for outpatients in Peking University Cancer Hospital from 2008 to 2017

目的分析北京大学肿瘤医院(以下简称我院)门诊近10年强阿片类药物用量趋势。方法采用等效剂量分析方法,比较2008—2017年总年人均用量及不同强阿片类药物年人均用量的趋势,并进一步分析短效与长效强阿片类药物的年人均用量差异。结果近10年我院门诊强阿片类药物的年人均用量呈递增趋势,2017年为2008年的2.11倍,其中长效制剂增长2.21倍,短效制剂减少31%。羟考酮缓释片年人均用量逐年大幅增加,2017年羟考酮缓释片的人均用量最大,占总年人均用量的69.79%;吗啡缓释片与吗啡片年人均用量趋势一致,表现为先增加后减少再趋于平稳;氨酚羟考酮片与芬太尼透皮贴剂的年人均用量均为逐年递增趋势。结论 2008—2017年我院门诊强阿片药物的使用趋于规范、合理。

ObjectiveTo analyzing the trend of strong opioid drugs consumption in the outpatient department of Beijing Cancer Hospital(hereinafter referred to as our hospital)in last ten years. MethodsEquivalent dose analysis method was used to compare the trend of the total annual per capita consumption and the annual per capita consumption of different strong opioid drugs from 2008 to 2017,and the difference of the annual per capita consumption of ordinary and sustained-release strong opioid drugs were further analyze.ResultsIn last ten years,the annual per capita consumption of strong opioid drugs for outpatient in our hospital showed an increasing trend.The per capita consumption in 2017 was 2.11 times as much as that in 2008.The sustained-release preparations increased by 2.21 times,while ordinary preparations decreased by 31%.The annual per capita consumption of oxycodone sustained-release tablets increased significantly year by year.In 2017,the per capita consumption of oxycodone sustained-release tablets was maximized,accounting for 69.79% of the total annual per capita consumption.The trend of per capita consumption of morphine sustained-release tablets and morphine tablets was the same,which showed that the annual per capita consumption was increased first,then decreased and stabilized.The annual per capita consumption of oxycodone tablets and fentanyl transdermal patches was increased year by year. ConclusionFrom 2008 to 2017,the use of strong opioid drugs for outpatients of our hospital tends to be standardized and reasonable.