非编码RNA与急性肾损伤相关性的研究进展

Research progress on the relationship between non-coding RNA and acute kidney injury

急性肾损伤(AKI)是一种以肾功能迅速下降、高死亡率为特征的常见严重疾病。然而,AKI的分子机制尚未明确,且缺乏有效的治疗方法。非编码RNA(nc RNAs)通过调控炎性反应、细胞程序性死亡、修复阶段的细胞周期等机制参与AKI发生的病理生理过程。因此,多种nc RNAs不仅被视为AKI的新型生物标志物,而且有望成为潜在的治疗靶点。本文综述了ncRNAs在AKI中的变化、功能及潜在治疗作用。

Acute kidney injury (AKI) is a common serious disease characterized by rapid decline in renal function and high mortality. However, the molecular mechanism of AKI is still unclear and there is no effective treatment. Non-coding RNA (ncRNAs) participate in the pathophysiological process of AKI by regulating inflammatory response, programmed cell death and cell cycle in repair phase. Therefore, a variety of ncRNAs are not only considered as new biomarkers of AKI, but also potential therapeutic targets. This article reviews the changes, functions and potential therapeutic effects of ncRNAs in AKI.