摘要
胃癌细胞对化疗药物不敏感,产生耐药性是导致高死亡率的主要原因。上皮间质转化(EMT)在胃癌的进展中起到重要作用,越来越多证据表明EMT通过相关转录因子、细胞因子、重要信号通路、调节干性等参与了胃癌细胞化疗耐药性的产生。本研究就胃癌的EMT与化疗耐药关系的研究进展作一综述,以助于在胃癌抗耐药治疗中找到新的策略。
Insensitivity of tumor cells to chemotherapeutic agents and arising drug resistance are the main cause of high mortality in gastric cancer. Epithelial mesenchymal transformation (EMT) plays an important role in the progression of gastric cancer. There is mounting evidence demonstrating that EMT participates in gastric cancer chemotherapeutic drug resistance through related transcription factors, cytokines, important signaling pathways, and regulation of stemness. This article summarizes the relationship between EMT and chemoresistance in gastric cancer to help people find new strategies in anti-drug-resistant treatment of gastric cancer.
作者
陈梦娇
徐岷
CHEN Mengjiao;XU Min(School of Medicine, Jiangsu University, Jiangsu Province, Zhenjiang 212000, China;Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu Province, Zhenjiang 212000, China)
出处
《中国医药导报》
CAS
2019年第13期46-49,共4页
China Medical Herald
基金
江苏省“六大人才高峰”资助项目(2014-WSW-038)
关键词
胃癌
上皮间质转化
化疗
耐药性
Gastric cancer
Epithelial-mesenchymal transition
Chemotherapy
Drug resistance
