支架蛋白IQGAP3在肿瘤中的作用及研究进展

Advances of functions of IQGA3 and its research on tumor

IQGAP3是新近发现的支架蛋白家族成员之一,能与多种信号通路关键分子结合的一种骨架蛋白。通过与目的蛋白相互作用,参与信号通路的整合和细胞生物功能学的调节。近年来众多研究发现,IQGAP3可通过促进肿瘤细胞增殖,增强细胞侵袭能力,降低细胞间黏附性从而在肿瘤的发生发展中扮演重要角色。

IQGAP3 is a newly discovered member of the scaffold protein family.By interacting with its target proteins,IQGAP3 participates in many signaling pathways and regulation cellular function.In recent years,many studies have found that IQGAP3 plays an important role in tumorigenesis and development by promoting tumor cell proliferation,enhancing cell invasion and reducing intercellular adhesion.