间苯三酚注射液联合固肾安胎丸治疗先兆流产的临床效果

Clinical effect of Phloroglucinol Injection combined with Gushen Antai Pills in treatment of threatened abortion

目的探讨间苯三酚注射液联合固肾安胎丸对先兆流产孕妇的影响。方法选取2016年2月~2018年4月深圳市罗湖区妇幼保健院接收的109例先兆流产孕妇,根据随机数表法将患者分为对照组(54例)和研究组(55例),对照组孕妇给予间苯三酚注射液治疗,研究组孕妇给予间苯三酚注射液联合固肾安胎丸治疗。比较两组患者治疗后临床疗效,比较两组孕妇治疗前后血清学指标[人绒毛膜促性腺激素(β-HCG)、雌二醇(E2)以及孕酮(P)],记录两组治疗期间不良反应发生情况。结果研究组孕妇治疗后总有效率高于对照组孕妇(P<0.05)。两组孕妇治疗后β-HCG、E2、P均较治疗前升高(P<0.05),且研究组高于对照组(P<0.05)。研究组临床症状消失时间、宫缩消失时间均短于对照组(P<0.05)。两组孕妇治疗期间不良反应发生率差异无统计学意义(P>0.05)。结论间苯三酚注射液联合固肾安胎丸治疗先兆流产效果显著,可有效改善患者临床症状,改善相关血清学指标水平,且不增加不良反应发生率,具有一定的临床应用价值。

Objective To explore the effect of phloroglucinol injection combined with Gushen Antai Pills in the treatment of threatened abortion.Methods From February 2016 to April 2018,109 pregnant women with threatened abortion admitted in Luohu District Women and Children′s Health Care Hospital of Shenzhen were selected,and they were divided into control group(54 cases)and study group(55 cases)according to the random number table method.The pregnant women in control group were treated with Phloroglucinol Injection,and the pregnant women in study group were treated with Phloroglucinol Injection combined with Gushen Antai Pills.The clinical efficacy was compared between the two groups,the serum index[human chorionic gonadotropin(β-HCG),estradiol(E2)and progesterone(P)]of the two groups were compared before and after treatment,the adverse reaction of the two groups during treatment was recorded.Results After treatment,the total effective rate of study group was higher than that of the control group(P<0.05).After treatment,the levels ofβ-HCG,E2 and P were higher than before treatment(P<0.05),and these in the study group were higher than those in the control group(P<0.05).The disappearance time of clinical symptoms and uterine contraction in the study group were shorter than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions in the two groups during the treatment period(P>0.05).Conclusion Phloroglucinol Injection combined with Gushen Antai Pills is effective in the treatment of threatened abortion.It can effectively improve the clinical symptoms of patients,improve the level of related serum indexes,and it does not increase the incidence of adverse reactions.It has a certain clinical value.