西替利嗪滴剂联合布地奈德混悬液对小儿哮喘急性发作FENO和SOD的影响

Effects of Cetirizine drops combined with Budesonide Suspension on FENO and SOD in children with acute asthma

目的探讨西替利嗪滴剂联合布地奈德混悬液雾化吸入治疗对小儿哮喘急性发作的治疗及其对血清超氧化物歧化酶(SOD)和呼出气一氧化氮(FENO)的影响。方法选取2014年7月~2017年2月于河北省唐山市人民医院就诊的急性哮喘急性发作的140例患儿作为研究对象,并将其随机分为对照组(n=71)和观察组(n=69)。对照组在对症治疗的基础上接受布地奈德混悬液雾化吸入治疗,观察组在对症治疗的基础上口服西替利嗪滴剂联合布地奈德混悬液雾化吸入治疗。比较两组治疗总有效率、第一秒用力呼气容量(FEV1)、FEV1占预计值的百分比(FEV1%)、血清SOD活性、FENO含量。结果对照组的总有效率低于观察组,差异有统计学意义(P<0.05)。两组治疗前FEV1、FEV1%、血清SOD活性、FENO含量比较,差异无统计学意义(P>0.05)。两组治疗后FEV1、FEV1%、血清SOD活性均高于治疗前,而FENO含量低于治疗前,差异均有统计学意义(P<0.05)。对照组治疗后FEV1、FEV1%、SOD活性均低于观察组,而其FENO含量高于观察组,差异均有高度统计学意义(P<0.01)。结论相较于单纯使用布地奈德混悬液治疗,西替利嗪滴剂联合布地奈德混悬液能有效缓解小儿哮喘急性发作,改善肺功能,增加血清SOD活性,降低FENO含量。

Objective To investigate the effect of Cetirizine drops combined with Budesonide Suspension aerosol inhalation on acute attack of asthma in children and its effects on serum superoxide dismutase(SOD)and exhaled nitric oxide(FENO).Methods A total of 140 children with acute asthma exacerbations from July 2014 to February 2017 in Tangshan People′s Hospital of Hebei Province were enrolled and randomly divided into control group(n=71)and observation group(n=69).The control group received Budesonide Suspension inhalation therapy on the basis of symptomatic treatment,while the observation group received Cetirizine drops combined with Budesonide Suspension aerosol inhalation treatment on the basis of symptomatic treatment.The total effective rate,the first second forced expiratory volume(FEV1),the percentage of FEV1 in the predicted value(FEV1%),serum SOD activity and FENO content were compared between the two groups.Results The total effective rate of the control group was lower than that of the observation group(P<0.05).There was no significant difference in FEV1,FEV1%,serum SOD activity and FENO content between the two groups before treatment(P>0.05).After treatment,FEV1,FEV1%and serum SOD activity in the two groups were higher than those before treatment,while FENO content was lower than that before treatment,the differences were statistically significant(P<0.05).After treatment,the FEV1,FEV1%and SOD activity in the control group were lower than those in the observation group,while the content of FENO in the control group was higher than that in the observation group,with statistical significance(P<0.01).Conclusion Compared with Budesonide Suspension alone,Cetirizine drops combined with Budesonide Suspension can effectively alleviate acute attack of asthma in children,improve lung function,increase serum SOD activity and reduce FENO content.