宣肺宁嗽汤加减治疗感冒后咳嗽临床研究

Clinical Study on Modified Xuanfei Ningsou Decoction in Treatment of Post Infectious Cough

目的观察宣肺宁嗽汤加减治疗感冒后咳嗽临床疗效。方法采用随机数字表法将106例感冒后咳嗽患者分为治疗组和对照组各54例。治疗组予宣肺宁嗽汤加减,每次200 mL,早晚餐后温服。对照组予苏黄止咳胶囊,每次3粒,每日三餐后30 min口服。2组均连续治疗1周。观察2组治疗3、5、7 d临床疗效、咳嗽症状积分,记录起效时间及症状消失时间,比较2组血白细胞水平,监测不良反应。结果治疗3 d,治疗组总有效率为59.26%,高于对照组的40.39%(P<0.05);治疗5d,治疗组总有效率为64.82%,高于对照组的42.31%(P<0.01);治疗7 d,治疗组总有效率为88.90%,与对照组的80.77%比较,差异无统计学意义(P>0.05)。与本组治疗前比较,2组治疗3、5、7 d咳嗽症状积分明显降低(P<0.05,P<0.01);2组治疗3、5 d比较,治疗组咳嗽症状积分低于对照组(P<0.05)。治疗组起效时间、症状消失时间短于对照组(P<0.05)。2组血白细胞分类计数比较差异无统计学意义(P>0.05)。2组均未见严重不良反应。结论宣肺宁嗽汤加减治疗感冒后咳嗽疗效满意,与苏黄止咳胶囊疗效相当,起效更快。

Objective To observe the clinical efficacy of modified Xuanfei Ningsou Decoction for the treatment of post infectious cough (PIC). Methods Totally 106 patients with PIC were divided into the treatment group and the control group by random number table method, with 54 cases in each group. The treatment group was given modified Xuanfei Ningsou Decoction, 200 mL each time, warmly taken after breakfast and supper. The control group was given Suhuang Zhike Capsules, three capsules per time, orally taken 30 min after three meals. The treatment for both groups lasted for one week. The clinical efficacy and cough symptom scores of both groups on 3, 5, 7 d of treatment were observed. The onset time and symptom disappearance time were recorded. The blood leukocyte levels of both groups were compared. Adverse reactions were monitored. Results On 3 d of treatment, the total effective rate of the treatment group was 59.26%, which was higher than that of the control group (40.39%), with statistical significance (P<0.05);On 5 d of treatment, the total effective rate of the treatment group was 64.82%, which was higher than that of the control group (42.31%), with statistical significance (P<0.01);On 7 d of treatment, the total effective rate of the treatment group was 88.90% compared with 80.77% of the control group, with no statistical significance (P>0.05). Compared with before treatment, the scores of cough symptoms in both groups significantly decreased on 3, 5, and 7 d of treatment (P<0.05, P<0.01). The scores of cough symptoms in the treatment group were lower than those in the control group at 3 and 5 days after treatment (P<0.05). The onset time and symptom disappearance time of the treatment group were shorter than those of the control group (P<0.05). There was no statistical significance in the classification of white blood cells between the two groups (P>0.05). No serious adverse reactions were observed in both groups. Conclusion The efficacy of modified Xuanfei Ningsou Decoction for the treatment of PIC is as effective as Suhuang Zhike Capsules, with faster effects.