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皖南地区脑卒中人群亚甲基四氢叶酸还原酶基因多态性特点分析 被引量:2

Analysis on the polymorphism of methylenetetrahydrofolate reductase gene in stroke population in southern Anhui province
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摘要 目的:分析皖南地区脑卒中人群亚甲基四氢叶酸还原酶基因多态性特点。方法:从弋矶山医院药剂科获取2016年5月~2018年3月所有行脑卒中风险基因检测患者的基本信息和检测结果,排除非脑卒中和非皖南地区患者后进行分组。结果:皖南地区脑卒中人群中rs1801133(C677T)变异率为67.03%,其中纯合型变异率为19.02%。结论:皖南地区脑卒中人群亚甲基四氢叶酸还原酶基因突变发生率较高。 Objective:To analyze the polymorphism of methylenetetrahydrofolate reductase gene in stroke population in southern Anhui province.Methods:The basic information and test results were retrieved from all patients with stroke risk genes undergone test in the Department of Pharmacy in our hospital between May 2016 and March 2018.Cases of non-stroke and population outside southern Anhui areas were excluded,and the eligible cases were included in current study.Results:The mutation rate of rs1801133 (C677T) in the stroke population from southern Anhui was 67.03%,and the homozygous mutation rate (TT) was 19.02%.Conclusion:The incidence of methylenetetrahydrofolate reductase gene mutation appears higher in stroke patients from southern Anhui areas.
作者 栾迪 丁言运 王雅平 许慧芳 赵守财 LUAN Di;DING Yanyun;WANG Yaping;XU Huifang;ZHAO Shoucai(Department of Neurology,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)
出处 《皖南医学院学报》 CAS 2019年第3期227-230,共4页 Journal of Wannan Medical College
基金 国家自然科学基金项目(81371295) 芜湖市科技惠民计划(2015hm06)
关键词 皖南地区 5 10-亚甲基四氢叶酸还原酶 rs1801133 基因多态性 脑卒中 southern Anhui province MTHFR rs1801133 gene polymorphism stroke
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