巴曲亭在输尿管镜治疗输尿管嵌顿性结石中的应用

Applying hemocoagulase bothrops atrox to impacted ureteral calculi in ureteroscopy

目的:探讨巴曲亭在输尿管镜治疗输尿管嵌顿性结石手术中的止血效果及其安全性。方法:搜集2017年4月~2018年9月在我院行输尿管镜钬激光碎石术的输尿管嵌顿性结石患者的资料,根据术前是否预防性应用巴曲亭分为治疗组和对照组,并比较两组围手术期的相应指标。结果:治疗组的Hb下降值、肉眼血尿时间及尿管留置时间均少于对照组。两组术后感染、肾绞痛、结石残留等并发症的发生率差异无统计学意义。两组术前各项凝血指标之间的比较差异均无统计学意义。两组术后PT、APTT、Fib都较术前下降,差异有统计学意义;但两组术后PT、APTT、Fib指标治疗效果差异无统计学意义。结论:巴曲亭在输尿管镜治疗输尿管嵌顿性结石手术中的止血效果确切,而且安全可行,值得推广。

Objective:To assess the hemostatic effect and safety of hemocoagulase bothrops atrox for injection in the treatment of impacted ureteral calculi in ureteroscopy. Methods:The clinical data were collected on patients with impacted ureteral calculi undergone ureteroscopic holmium laser lithotripsy in our hospital between April 2017 and September 2018.The cases were divided into treatment group and control group by history of preoperative prophylactic use of hemocoagulase bothrops atrox for injection,and compared concerning the perioperative indexes. Results:Patients in the treatment group had decreased Hb level,less duration of macroscopic haematuria and shortened urinary catheter indwelling,yet the difference was insignificant the incidence of postoperative infection,renal colic and residual calculus between groups.There was no statistical difference between groups in preoperative coagulation indexes,yet significantly decreased PT,APTT and Fib were seen in the two groups following surgery.However,the therapeutic effects on PT,APTT and Fib were not different between groups after operation. Conclusion:Hemocoagulase bothrops atrox for injection can be safe and effective in hemostasia for patients with impacted ureteral calculi undergoing ureteroscopy,and is worthy of wider clinical recommendation.