芜湖某医院389例泌尿系结石成分分析

Analysis on the urinary stone composition in 389 cases in a hospital in Wuhu area

目的:对芜湖及周边地区泌尿系结石患者结石成分进行分析,为本地区结石患者的预防性治疗提供依据。方法:收集2016年3月~2018年10月期间于弋矶山医院泌尿外科住院且手术取出或自行排出而确诊的389例泌尿系结石患者结石标本,用红外光谱进行成分分析,得出相关结论。结果:389例泌尿系结石标本中男性患者254例,女性患者135例,男女比例1.88∶1。上尿路结石占总人数的93.83%,下尿路结石占总人数的6.17%。男性患者结石成分以草酸钙为主,女性患者结石成分以碳酸磷灰石为主。在所有泌尿系结石患者中,含有草酸钙成分的男性患者比例高于女性患者(P<0.05);含有碳酸磷灰石、无水尿酸及六水磷酸铵镁成分的男性患者比例低于女性患者(P<0.05);而含有尿酸铵、尿酸钠、磷酸氢钙、L-胱氨酸和羟基磷灰石成分的患者在男女患者间差异无统计学意义(P>0.05)。结论:芜湖及周边地区泌尿系结石患者中,上尿路结石患者多于下尿路结石患者,混合型结石患者多于单一型结石患者,草酸钙是主要的结石成分,结石和性别有关联。

Objective:To analyze the components of urinary calculi in population in Wuhu area for theoretical evidence in prevention and treatment of this condition.Methods:Urinary stone specimens(either surgical removal or spontaneous discharge) were obtained from 389 patients admitted to and treated in our department between March 2016 and October 2018,and subjected to detection of the composition by infrared spectroscopy.Results:Of the 389 cases,254 were males and 135 females.The male to female ratio was 1.88:1.Upper urinary stone accounted for 93.83%,and lower urinary stone,6.17%.The stone composition was primarily associated with calcium oxalate in males,and carbonate apatite in females.Incidence of calcium oxalate stone was higher in males than in females(P<0.05),yet males had lower proportion of apatite carbonate,anhydrous uric acid and magnesium ammonium hexahydrate stone composition than that of females(P<0.05).The stone composition involved in ammonium urate,sodium urate,calcium hydrophosphate,L-cystine and hydroxyapatite remained no significantly different between genders( P> 0.05).Conclusion:Upper urinary calculi and mixed calculi are more common in population living in Wuhu area.The stone composition is generally involved in calcium oxalate,and incidence of calculi is associated with gender.