应用非接触性眼表综合分析仪观察T2DM和/或高血压患者的眼表特征

Observation of ocular surface characteristics in patients with type 2 diabetes mellitus and/or hypertension by non-contact ocular surface analyzer

目的:使用非接触性眼表综合分析仪分析2型糖尿病(T2DM)和/或高血压患者眼表特征。方法:选取2017-01/2018-12在我院就诊的T2DM患者、高血压患者、T2DM合并高血压患者、无T2DM也无高血压患者各40例40眼,分析比较四组患者OSDI评分、泪河高度、眼红指数、角膜荧光素钠染色评分、非侵入性泪膜破裂时间(首次泪膜破裂时间和平均泪膜破裂时间)检测结果。结果:T2DM患者眼部不适的主观感受更为明显,T2DM和/高血压患者更容易出现眼部充血的体征。与无T2DM也无高血压的患者相比,T2DM患者的泪河高度降低,平均泪膜破裂时间明显缩短(均P<0.05),但四组患者的首次泪膜破裂时间、角膜荧光素钠染色评分均无明显差异(P>0.05)。结论:非接触性眼表综合分析仪能够无侵入地观察眼表特征,提供相对客观的量化检查结果。T2DM患者眼部稳定性较无T2DM也无高血压的患者下降,稳态更容易被打破。

AIM: To observe and analyze the ocular surface parameters in patients with type 2 diabetes mellitus and/or hypertension using non-contact ocular comprehensive surface analyzer. METHODS: Totally 160 patients were divided into four groups. And 40 patients were diagnosed with type 2 diabetes mellitus, 40 patients with hypertension, 40 patients with type 2 diabetes mellitus and hypertension, and 40 patients without type 2 diabetes mellitus and hypertension were selected from our hospital from January 2017 to December 2018. OSDI scores, tear meniscus height, eye red index, corneal fluorescein sodium staining scores, non-invasive tear film rupture time (first tear film rupture time and average tear film rupture time) were analyzed and compared among the four groups. RESULTS: The subjective perception of eye discomfort was more obvious in patients with T2DM. Patients with T2DM and/or hypertension were more likely to have eye congestion. Compared with the patients without T2DM and hypertension, the tear meniscus height and average tear film rupture time of T2DM patients were significantly reduced ( P <0.05). However, the first tear film rupture time and corneal fluorescein sodium staining score were not statistically different among the four groups ( P >0.05). CONCLUSION: Non-contact comprehensive ocular surface analyzer can observe the ocular surface characteristics of the patients non-invasively and provide relatively objective quantitative examination results. Ocular stability in patients with T2DM is lower than in patients without T2DM and hypertension, and ocular surface homeostasis of these patients is more likely to be broken.