终末期肾病腹膜透析患者血清鸢尾素水平与颈动脉粥样硬化及左心室肥厚相关性研究

Correlation between serum irisin level and carotid atherosclerosis and left ventricular hypertrophy in patients with end-stage renal disease undergoing peritoneal dialysis

目的:探讨终末期肾病腹膜透析患者血清鸢尾素水平与颈动脉粥样硬化及左心室肥厚相关性。方法:本院终末期肾病并行腹膜透析的患者118例为观察组,同期选择本院门诊健康体检者112例作为对照组,测定两组TC、TG、HDL-C、LDL-C、鸢尾素、LVMI、LVEF水平,分析血清鸢尾素水平与颈动脉粥样硬化及左心室肥厚相关性。结果:观察组收缩压、舒张压高于对照组,差异有统计学意义(t=15.352、12.455,P<0.05);观察组鸢尾素水平明显高于对照组,差异有统计学意义(t=14.350,P<0.05);观察组TC、TG、LDL-C水平高于对照组,HDL-C水平低于对照组,差异有统计学意义(t=12.452、13.092、14.012、15.813,P<0.05);观察组IMT、LVMI水平高于对照组,LVEF水平低于对照组,差异有统计学意义(t=13.509、14.120、15.913,P<0.05);鸢尾素与TC、TG、LDL-C、IMT、LVMI呈显著正相关,与HDL-C、LVEF呈显著负相关,差异有统计学意义(r=0.45、0.48、0.52、0.43、0.53、-0.42、-0.51,P<0.05);鸢尾素、TG均为终末期肾病腹膜透析患者发生颈动脉粥样硬化左心室肥厚的危险因素(OR=4.20、5.47,P<0.05)。结论:终末期肾病腹膜透析患者血清鸢尾素水平升高,其与颈动脉粥样硬化及左心室肥厚程度密切相关;鸢尾素、TG均为终末期肾病腹膜透析患者发生颈动脉粥样硬化左心室肥厚的危险因素,鸢尾素可作为预测病情的重要指标。

Objective: To investigate the relationship between serum irisin level and carotid atherosclerosis and left ventricular hypertrophy in patients with end-stage renal disease peritoneal dialysis. Methods: A total of 118 patients with end-stage renal disease and peritoneal dialysis were enrolled as the observation group in the hospital. 112 patients who underwent physical examination in the outpatient department were selected as the control group. The levels of TC, TG, HDL-C, LDL-C, irisin, LVMI and LVEF were measured. The correlation between serum irisin levels and carotid atherosclerosis, left ventricular hypertrophy was analyzed. Results: The systolic blood pressure and diastolic blood pressure of the observation group were higher than those of the control group ( t =15.352, 12.455, P <0.05). The level of irisin in the observation group was significantly higher than that in the control group ( t =14.350, P <0.05);the levels of TC, TG and LDL-C in the observation group were higher than those in the control group, and the HDL-C level was lower than that in the control group, the differences were statistically significant ( t =12.452, 13.092, 14.012, 15.813, P <0.05);The levels of IMT and LVMI in the observation group were higher than those in the control group, and the level of LVEF was lower than that in the control group. The differences were statistically significant ( t =13.509, 14.120, 15.913, P <0.05). Irisin had significant positive correlation with TC, TG, LDL-C, IMT, LVMI, and had negative significant correlation with HDL-C and LVEF. The differences were statistically significant ( r =0.45, 0.48, 0.52, 0.43, 0.53,-0.42 ,-0.51, P <0.05);irisin and TG were the risk factors for carotid atherosclerotic left ventricular hypertrophy in patients with end-stage renal disease peritoneal dialysis ( OR =4.20, 5.47, P <0.05). Conclusion: The serum irisin level of patients with end-stage renal disease peritoneal dialysis is increased, which is closely related to carotid atherosclerosis and left ventricular hypertrophy. Irisin and TG are the risk factors of carotid atherosclerotic left ventricular hypertrophy in patients with end-stage renal disease peritoneal dialysis. Irisin can be used as an important indicator for predicting the condition.