鲁西地区妊娠妇女25-羟基维生素D营养状况初步研究

Nutritional status of 25-hydroxyvitamin D in pregnant women in western Shandong

目的了解鲁西地区妊娠妇女25-羟基维生素D[25(OH)D]水平现状,分析其与孕期、年龄、季节变化之间的关系,为指导本地区妊娠妇女合理补充维生素D提供依据。方法采用化学发光免疫分析法对11193例健康妊娠妇女和305例健康非妊娠妇女进行血清25(OH)D水平检测,分析不同孕期、不同季节、不同年龄段妊娠妇女25(OH)D浓度水平和缺乏状况。结果11193例妊娠妇女25(OH)D缺乏、不足和充足检出率分别为81.89%、15.38%、2.73%,平均水平为(14.19±6.76)ng/ml,明显低于非妊娠妇女。早孕期25(OH)D水平明显低于中、晚孕期。冬季25(OH)D缺乏率最高,夏季最低。16岁~23岁和36岁~45岁妊娠妇女25(OH)D缺乏率明显高于24岁~29岁。结论鲁西地区妊娠妇女普遍存在维生素D缺乏,应采取干预措施,促进母婴健康。

Objective To understand the status of 25 - hydroxyvitamin D [25( OH) D] in pregnant women in west Shandong, and to analyze the relationship with pregnancy, age, and seasonal changes, so as to provide basis for guiding the rational supplement of vitamin D in the pregnant women in that region. Methods The serum levels of 25( OH) D were detected by chemiluminescence immunoassay in 11 193 healthy pregnant women and 305 healthy non pregnant women. The level and deficiency of 25( OH) D in different pregnancy, different season and different age groups were analyzed. Results The deficiency, deficiency and adequacy rates of 25 ( OH) D were 81. 89%, 15. 38%, 2. 73% in 11 193 pregnant women, and the average level was ( 14. 19 ± 6. 76) ng /ml, significantly lower than that of non pregnant women. The level of 25( OH) D in early pregnancy was significantly lower than that in the second and third trimesters. The 25( OH) D deficiency rate was the highest in winter and the lowest in summer. The 25( OH) D deficiency rates of pregnant women aged from 16 to 23 and from 36 to 45 were significantly higher than that from 24 to 29. Conclusion Vitamin D deficiency is prevalent in pregnant women in western Shandong. Interventions should be taken to promote maternal and child health.