Rab蛋白与骨质疏松症关系浅析

Analysis of the relationship between Rab protein and osteoporosis

随着人口老龄化进程的不断推进,骨质疏松症的发病率逐年升高。Rab蛋白作为一类具有特殊生物学活性的小分子蛋白,广泛存在于真核细胞中。骨髓间充质干细胞所分泌的外泌体可携带Rab蛋白,并能定向运输到靶标以发挥其独有的生物学作用,从而达到调控骨质疏松症发生、发展的目的。笔者基于近年来的国内外文献研究,总结Rab蛋白与骨质疏松症之间的联系,为骨质疏松症的防治提供新的研究方向。

With the continuous advancement of the aging process in the population, the incidence of osteoporosis is getting higher and higher. Rab protein is a kind of small molecule protein with special biological activity, which is widely expressed in eukaryotic cells. The exosomes secreted by bone marrow mesenchymal stem cells can carry Rab protein, and can transport it to the target to play its unique biological role, Resultsing in the regulation of the occurrence and development of osteoporosis. Based on recent national and international literature research, this article summarizes the link between Rab protein and osteoporosis and provides new research directions for the prevention and treatment of osteoporosis.