肝细胞癌的失巢凋亡抵抗作用研究进展

Advances in Research on anoikis resistance of hepatocellular carcinoma

失巢凋亡抵抗作用赋予失去粘附作用的癌细胞在血液循环中存活并转移的能力,但是其在肝细胞癌肝内及远处转移过程中的作用及机制尚未完全明确。近年的研究表明某些因子或药物通过一些信号通路抑制肝癌细胞的失巢凋亡。这些信号通路并不是完全分离的,而是相互联系、相互作用共同促进肝细胞癌转移。肝脏是许多物质的代谢中心,很多相关因素可通过失巢凋亡抵抗促进肝细胞癌转移。本文主要就肝细胞癌发生失巢凋亡抵抗作用的信号通路做一综述。

The anoikis resistance confers the ability of cancer cells to survive and metastasize in the blood circulation without adhesion, but its effect and mechanism in intrahepatic and distant metastasis of hepatocellular carcinoma has not been fully elucidated. Recent studies have shown that certain factors or drugs may inhibit anoikis of hepatoma cells through some signaling pathways. These signaling pathways are not completely separated, they are interconnected to promote metastasis of hepatocellular carcinoma. Liver is the metabolic center of many substances, and many related factors can promote metastasis of hepatocellular carcinoma through inhibiting anoikis. In this review, we summarized the signaling pathways of anoikis resistance of hepatocellular carcinoma.