中医药干预干眼病的临床及实验研究进展

Clinical and experimental research progress of traditional Chinese medicine in the treatment of dry eye disease

综述中医药干预干眼病的临床及实验研究进展。临床研究方面,依据干眼病的病因病机,对肝肾阴虚型、肺阴不足型、肝郁阴虚型、肝旺脾虚型等不同证型的干眼病患者进行辨证论治,采用中药方剂内服、中药滴眼液外用、针灸等中医药疗法能显著改善患者的症状,增加其泪液分泌量,延长泪膜破裂时间;实验研究方面,多种中药复方、单味药、提取物及单体对药物(如东莨菪碱、阿托品、高渗盐水)和手术(如去势、腺体摘除)诱导的干眼病动物模型具有治疗作用,其作用机制与免疫、炎症、氧化应激、细胞凋亡、激素等相关。

This paper reviews the clinical and experimental research progress of traditional Chinese medicine(TCM) intervention on dry eye disease. In clinical research, according to the etiology and pathogenesis of dry eye disease, for the patients of dry eye disease with different syndromes, such as syndrome of yin deficiency of liver and kidney, syndrome of lung yin deficiency, syndrome of liver stagnation and yin deficiency and syndrome of liver hyperactivity and spleen deficiency, syndrome differentiation and treatment are performed. The TCM therapies including Chinese medicine prescriptions for oral administration, Chinese medicine eye drops for external application and acupuncture can significantly improve the symptoms of patients, increase the amount of tear secretion, and prolong the breakup time of tear film. In experimental research, a variety of Chinese medicine compound recipes, single herb drugs, extracts and monomers show the therapeutic effects on drugs(such as scopolamine, atropine, hypertonic saline) and surgery(such as castration, glandectomy) induced animal models of dry eye disease. The mechanism is related to immunity, inflammation, oxidative stress, apoptosis, hormones and so on.