壳聚糖/海藻酸钠/多孔淀粉-茶树精油微胶囊制备及释放性能分析

Preparation and Release Behavior Analysis of Chitosan/Sodium Alginate/Porous Starch-Tea Tree Essential Oil Microcapsule

以多孔淀粉(PS)为芯材载体吸附茶树精油(TTEO),以海藻酸钠(SA)-壳聚糖(CS)为壁材,戊二醛(GA)为固化交联剂,通过聚电解质复合凝聚法成功制备了CS/SA/PS-TTEO微胶囊。优化后的制备条件为:多孔淀粉与茶树精油的最佳比例为0.88∶1,海藻酸钠浓度为3.0%,壳聚糖浓度为3.0%,戊二醛浓度为2.0%,反应温度为30℃。采用透射电子显微镜(TEM)、热重分析(TGA)、红外光谱(FT-IR)、稳定性测试和释放率实验对CS/SA/PS-TTEO微胶囊的形成、性质和释放行为进行了分析。结果表明,CS/SA/PS-TTEO微胶囊在敞开体系中,TTEO的14天累积释放率为15.77%,单日释放率最低为0.20%;在封闭体系中14天累积释放率为7.37%,在10天左右释放趋于平稳,单日释放率最低仅为0.04%,表明CS/SA/PS-TTEO微胶囊具有一定的缓释能力。在-18～50℃温度下,CS/SA/PS-TTEO微胶囊与化妆品常用溶剂可稳定共存,此性质有利于提高TTEO类化妆品储存和运输稳定性。

The microcapsules of chitosan/sodium alginate/porous starch-tea tree essential oil(CS/SA/PS-TTEO) were successfully prepared by polyelectrolyte complex coacervation method with PS as the core material carrier to adsorb TTEO, SA-CS as the wall material, and glutaraldehyde(GA) as crosslinker. The preparation conditions were optimized as follows. The optimum ratio of PS to TTEO was 0.88∶1, the concentration of SA was 3.0%, the concentration of CS was 3.0%, the concentration of GA was 2.0%, and the reaction temperature was 30℃. The formation, properties and release behaviors of CS/SA/PS-TTEO microcapsules were analyzed by scanning electron microscope(TEM), thermogravimetry(TGA), Fourier transform infrared spectroscopy(FT-IR), stability test and release rate experiments. The results showed that in the open system, cumulative release rate of CS/SA/PS-TTEO microcapsules for 14 days was 15.77%, and the lowest release rate for a single day was 0.20%. In the closed system, the cumulative release rate of 14 days was 7.37%, and the release rate tended to be stable in about 10 days, with the lowest release rate of 0.04% in a single day, which proved that CS/SA/PS-TTEO microcapsules had the ability of slow release. CS/SA/PS-TTEO microcapsule was stable at-18℃ to 50℃ in the commonly used cosmetic solvent, and this property was beneficial to improve the stability of the storage and transport of cosmetics containing TTEO.