胆道闭锁肝脏血管系统改变的研究进展

Research advances in the changes of hepatic vascular system in biliary atresia

胆道闭锁(biliary atresia,BA)是一种发生于婴幼儿时期、进行性的严重肝内外胆道梗阻性疾病。Kasai手术是BA的首选治疗方法,但术后肝脏纤维化和肝硬化是制约BA患儿自体肝生存的关键因素。研究发现BA患儿肝脏血管存在异常,异常的血管系统对于BA的病因、诊断、肝纤维化进展等方面具有重要作用。本文就BA肝脏血管系统的形态学改变及其与纤维化的关系作一综述。

Biliary atresia (BA) is a progressive and severe obstructive disease of bile tract in infants.Kasai’s procedure is a preferred treatment for BA.However,liver fibrosis and cirrhosis are two key factors of restricting the survival of native liver.Researches have indicated that hepatic vascular changes and expression of related factors play an important role in the etiology,diagnosis and disease progression of BA.This paper reviewed the morphological changes of liver vascular system and its relationship with fibrosis in BA.