解毒化瘀法治疗毒瘀交阻型胃癌前病变临床研究

Clinical Study on the Treatment of Precancerous Lesions of Gastric Cancer with Toxin-Stasis Interaction by “Detoxification and Phlegm Resolving Method”

目的观察解毒化瘀法治疗毒瘀交阻型胃癌前病变(PLGC)的临床疗效.方法将190例PLGC患者随机分为治疗组及对照组各95例,治疗组91例予以特定处方用药煎剂治疗,对照组87例予以维酶素片口服,2月为1疗程,3个疗程后比较两组患者症状积分变化,评价临床疗效.结果治疗组有效率82.42%,对照组有效率68.97%,治疗组疗效优于对照组,其差异有统计学意义(P<0.05).治疗前后症状积分比较,治疗组在改善胃痛、痞胀、灼热、纳差、嘈杂等症状疗效优于对照组,差异有统计学意义(P<0.01,P<0.05).结论解毒化瘀法对毒瘀交阻型PLGC患者的临床症状有明显改善作用,有待进一步推广应用.

Objective To observe the clinical effect of "Detoxification and Phlegm Resolving Method" in the treatment of Precancerous Lesions of Gastric Cancer(PLGC).Methods 190 patients with PLGC were randomly divided into treatment group and control group. The treatment group was treated with specific prescription decoction, while the control group was treated with vermectin tablets orally. The course of treatment was 2 months. After 3 courses, the changes of symptom scores were compared between the two groups, and the clinical efficacy was evaluated. Results The effective rate of the treatment group was 82.42%, and that of the control group was 68.97%. The curative effect of the treatment group was better than that of the control group, and the difference was statistically significant(P > 0.05). Comparing the scores of symptoms before and after treatment, the curative effect of the treatment group was better than that of the control group in improving the symptoms of stomachache, swelling, burning, nausea, noise, etc.(P < 0.01, P < 0.05). Conclusion "Detoxification and phlegm resolving method" has a significant improvement effect on the clinical symptoms of PLGC patients with toxin-stasis interaction, which needs further promotion and application.