摘要
甘草是一味对人体较好的固本中草药,常用于治疗脏器寒热、饮食中毒、伤寒、喉咙疼痛、肺热咳嗽、稚童病症等症状。近年来的研究发现,甘草提取物亦有良好的抗癌功效,18β-甘草次酸通过前体甘草酸水解制得,是相对高效的抗癌成分。18β-甘草次酸可通过遏制癌细胞增殖、诱导癌细胞凋亡、遏制癌细胞侵袭转移、抗氧化、遏制新血管生成、遏制淋巴管生成、调节激素分泌等途径发挥抗癌作用。对18β-甘草次酸的抗癌机制研究进展进行了综述,旨在为后续研究提供参考。
Glycyrrhiza uralensis is a commonly used traditional Chinese medicine to treat the symptoms of organ fever, food poisoning, typhoid fever, sore throat, cough due to lung heat, children′s diseases and so on. In recent years, it has been found that the extract of Glycyrrhiza uralensis has good anti -cancer activity. 18β-glycyrrhetic acid, one of the main components in the extract of Glycyrrhiza uralensis, is found to have good anti-cancer activity. It can be obtained by hydrolysis of its precursor of glycyrrhizic acid. 18β-glycyrrhetinic acid exerts its anti-cancer effects by inhibiting cancer cell proliferation, inducing apoptosis of cancer cells, suppressing invasion and metastasis of cancer cells, preventing oxidation, prohibiting neovascularization and lymphangiogenesis, and regulating hormone secretion. The research progress of anti -cancer mechanism of 18β-glycyrrhetinic acid was reviewed, in hoping to provide references for the subsequent associated researches.
作者
王诗浓
张宇
张彤
王加茹
徐宛婷
张翼
罗英花
金成浩
WANG Shi-nong;ZHANG Yu;ZHANG Tong;WANG Jia-ru;XU Wan-ting;ZHANG Yi;LUO Ying-hua;JINCheng-hao(College of Life Science and Technology,Heilongjiang Bayi Agricultural University,Daqing 163319,China)
出处
《畜牧与饲料科学》
2019年第5期78-81,共4页
Animal Husbandry and Feed Science
基金
黑龙江省科学基金项目(LC2015036)
黑龙江省博士后科研启动自足项目(LBH-Q13132)
关键词
18Β-甘草次酸
中草药
抗癌机制
18β-glycyrrhetinic acid
traditional Chinese medicine
anti-cancer mechanism