超敏C反应蛋白、血脂与颈部血管斑块钙化的关系

Relationship between hypersensitive C-reactive protein, blood lipid and cervical vascular plaque calcification

目的探讨超敏C反应蛋白(hs-CRP)、血脂与颈部血管斑块钙化的关系。方法将我院收治的196例缺血性脑血管病患者(包括TIA及脑梗死)依据CTA检查分为颈动脉斑块钙化组和颈动脉斑块非钙化组,测定两组的血清甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和hs-CRP水平,并进行对比研究及相关性分析。结果196例缺血性脑血管病患者CTA检查结果示,颈动脉斑块钙化者90例,颈动脉斑块非钙化者106例;颈动脉斑块钙化组的血清HDL水平显著低于颈动脉斑块非钙化组,而hs-CRP水平高于颈动脉斑块非钙化组(P<0.05);简单线性回归分析结果显示,所有受试者血清hs-CRP与TG、LDL呈正相关(r=0.356、0.281,P<0.05),与HDL呈负相关(r=-0.151,P<0.05)。结论hs-CRP与颈部血管斑块钙化有关联;血脂是影响hs-CRP的主要独立因素。

Objective To investigate the relationship between hypersensitive C-reactive protein (hs-CRP), blood lipid and cervical vascular plaque calcification.Methods A total of 196 patients with ischemic cerebrovascular disease (including TIA and cerebral infarction) admitted in our hospital were divided into carotid calcified plaque group and non-carotid calcified plaque group according to the CTA examination, and the levels of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and hs-CRP in the two groups were measured for comparative study and correlation analysis.Results CTA results of 196 patients with ischemic cerebrovascular disease showed that 90 cases had carotid calcified plaque and 106 cases had non-carotid calcified plaque.The serum HDL level in the carotid calcified plaque group was significantly lower than that in the non-carotid calcified plaque group, while the hs-CRP level was higher than that in the non-carotid calcified plaque group (P<0.05).Simple linear regression analysis showed that serum hs-CRP was positively correlated with TG and LDL (r=0.356, 0.281, P<0.05) and negatively correlated with HDL (r=-0.151, P<0.05).Conclusion Hs-CRP is associated with cervical vascular plaque calcification, and blood lipid is the main independent factors affecting hs-CRP.