46例晚期前列腺癌患者内分泌治疗后PSA动态变化的临床分析

Clinical analysis of dynamic changes of PSA in 46 patients with advanced prostate cancer after endocrine therapy

目的探讨晚期前列腺癌患者经内分泌治疗后前列腺特异性抗原(PSA)的动态变化情况与疾病自身进展和生存预后情况的相关性。方法检测46例晚期前列腺癌患者血清标本中PSA值,比较其变化水平与患者生存时间之间的关系。结果PSA谷值<0.2ng/mL患者的总生存率及疾病无进展生存率均明显高于PSA谷值≥0.2ng/mL患者,差异有统计学意义(P=0.008;P=0.033)。PSA达谷时间≥10个月患者总生存率及疾病无进展生存率均明显高于PSA达谷时间<10个月患者,差异有统计学意义(P<0.001;P<0.001)。结论PSA谷值、PSA达谷时间与患者的总生存率及疾病无进展生存率之间具有明显相关性,PSA动态变化可以预测晚期前列腺癌患者内分泌治疗的预后。

Objective To investigate the correlation between the dynamic changes of prostate specific antigen (PSA) and the disease progression and survival prognosis in patients with advanced prostate cancer after endocrine therapy.Methods Serum PSA values were measured in 46 patients with advanced prostate cancer, and the relationship between PSA levels and survival time was compared.Results The total survival rate and disease progression-free survival rate of patients with PSA Valley<0.2 ng/mL were significantly higher than those with PSA Valley≥0.2 ng/mL, and the differences were statistically significant (P=0.008;P=0.033).The total survival rate and disease progression-free survival rate of patients with PSA valley time ≥10 months were significantly higher than those with PSA valley time <10 months (P<0.001;P<0.001).Conclusion There is a significant correlation between PSA valley and PSA Valley time and the total survival rate and disease progression-free survival rate of patients with advanced prostate cancer.Dynamic changes of PSA can predict the prognosis of endocrine therapy in patients with advanced prostate cancer.