短期胰岛素泵强化治疗对2型糖尿病患者血糖及胰岛β细胞功能的影响

Effects of short-term intensive insulin pump therapy on blood glucose and function of islet β cell in patients with type 2 diabetes mellitus

目的分析短期胰岛素泵强化治疗对2型糖尿病患者血糖及胰岛β细胞功能的影响。方法将100例2型糖尿病患者随机分为观察组(n=50,胰岛素泵治疗)与对照组(n=50,胰岛素注射治疗)。对比两组的血糖及胰岛素指标变化情况。结果与对照组比较,观察组的胰岛素用量更少、达标所需时间更短(P<0.05)。治疗后,观察组的FBG、2 h PBG、FPI、FPI/FIns、FIns、FIns/FBG、△I30/△G30、HBCI、AUCi、AUCi/AUCg均优于对照组及治疗前(P<0.05)。结论在2型糖尿病患者临床治疗中实施短期胰岛素泵强化治疗,可显著改善其血糖及胰岛素β细胞功能。

Objective To analyze the effects of short-term intensive insulin pump therapy on blood glucose and function of islet β cell in patients with type 2 diabetes mellitus. Methods A total of 100 patients with type 2 diabetes mellitus were randomly divided into observation group(n=50, insulin pump therapy) and control group(n=50, insulin injection therapy).The changes of blood glucose and insulin indexes of both groups were compared. Results Compared with the control group,the insulin dosage in the observation group was less and the time required to meet the standards was shorter(P<0.05). After treatment, FBG, 2 h PBG, FPI, FPI/FIns, FIns, FIns/FBG,△I30/△G30, HBCI, AUCi, AUCi/AUCg in the observation group were better than those in the control group and before treatment(P<0.05). Conclusion Short-term intensive insulin pump therapy can significantly improve blood glucose and function of islet β cell in patients with type 2 diabetes mellitus.