国产和进口格列齐特缓释制剂在初诊糖尿病治疗中的效果比较

Comparison on the Effects of Domestic and Imported Gliclazide Sustained-Release Preparations in the Treatment of Newly Diagnosed Diabetes Mellitus

目的比较国产与进口格列齐特缓释制剂应用于初诊糖尿病患者中的疗效。方法选择我院2017年11月至2019年6月的初诊糖尿病患者80例,随机分为两组各40例,国产组采用国产格列齐特缓释制剂,进口组采用进口格列齐特缓释制剂。对比两组的治疗效果。结果两组的总有效率和不良反应发生率比较差异无统计学意义(P>0.05)。治疗后,两组的FBG、 2hPG、HOMA-IR、 Hb A1c、 TC、 TG、 LDL-C及HDL-C水平均优于治疗前(P <0.05),但两组间比较无统计学差异(P>0.05)。国产组的成本效果比为0.695,低于进口组的3.000。结论国产与进口格列齐特缓释制剂在初诊糖尿病患者中的疗效相当,但国产格列齐特缓释制剂的成本更低,值得临床推广应用。

Objective To compare the curative effects of domestic and imported gliclazide sustained-release preparations in newly diagnosed diabetes mellitus. Methods 80 cases of patients with newly diagnosed diabetes mellitus in our hospital from November 2017 to June 2019 were selected and randomly divided into two groups, with 40 cases in each group. The domestic group used domestic gliclazide sustained-release preparation, and the imported group used imported gliclazide sustained-release preparation. The treatment effects of the two groups were compared. Results No statistical difference was found in the total effective rate and the incidence of adverse reactions between the two groups(P >0.05). After treatment, the levels of FBG, 2 h PG, HOMA-IR, HbA1 c, TC, TG, LDL-C and HDL-C of the two groups were better than those before treatment(P<0.05), but no statistical difference was found between the two groups(P >0.05). The cost-effectiveness ratio of the domestic group was 0.695, lower than 3.000 of the imported group. Conclusions Domestic and imported gliclazide sustained-release preparations have the same curative effect in patients with newly diagnosed diabetes mellitus, but the domestic gliclazide sustained-release preparation has lower cost and is worthy of clinical promotion and application.