血清降钙素原、C反应蛋白水平对急性加重期支气管扩张治疗中抗生素应用的参考价值

Reference Value of Serum Procalcitonin and C-Reactive Protein Levels on Antibiotic Application in the Treatment of Acute Exacerbation Bronchiectasis

目的分析血清降钙素原、 C反应蛋白水平对急性加重期支气管扩张治疗中抗生素应用的参考价值。方法选取我院2016年6月至2018年6月收治的100例急性加重期支气管扩张患者,分为A组和B组各50例。A组采用血清降钙素原指导,B组采用C反应蛋白指导,比较两组的治疗效果和相关治疗指标。结果两组的总有效率比较差异无统计学意义(P>0.05)。A组的抗生素使用时间、抗生素费用、住院时间均明显优于B组(P <0.05)。两组的真菌感染率比较差异无统计学意义(P>0.05)。结论抗生素应用于急性加重期支气管扩张治疗中,血清降钙素原和C反应蛋白均具有一定的参考价值,但血清降钙素原的参考价值略高于C反应蛋白。

Objective To analyze the reference value of serum procalcitonin and C-reactive protein levels on antibiotic application in the treatment of acute exacerbation bronchiectasis. Methods 100 cases of patients with acute exacerbation bronchiectasis admitted to our hospital from June 2016 to June 2018 were selected and divided into group A and group B, with 50 cases in each group. Group A was guided by serum procalcitonin, while group B was guided by C-reactive protein. The treatment effects and related treatment indicators of the two groups were compared. Results No statistical difference was found in the total effective rate between the two groups(P >0.05). The use time of antibiotics, antibiotic cost and hospitalization time of group A were significantly better than those of group B(P<0.05). No statistical difference was found in the mycotic infection rate between the two groups(P >0.05). Conclusions During the antibiotic application in the treatment of acute exacerbation bronchiectasis, serum procalcitonin and C-reactive protein have certain reference value, but serum procalcitonin has slightly higher reference value than C-reactive protein.