培元通脑胶囊联合尼莫地平对帕金森病患者认知功能及ADL评分的影响

Effect of Pei Yuan Tong Nao Capsule Combined with Nimodipine on Cognitive Function and ADL Score in Patients with Parkinson's Disease

目的探讨培元通脑胶囊联合尼莫地平在帕金森病(PD)治疗中的应用价值。方法选取2016年5月至2018年2月我院60例PD患者,按照随机数字表法分为观察组与对照组,每组30例。常规抗帕金森病治疗基础上,对照组予以尼莫地平治疗,观察组给予尼莫地平+培元通脑胶囊治疗,均连续治疗12周。对比两组临床疗效及治疗前后认知功能(MMSE评分)、日常生活自理能力(ADL评分)。结果观察组治疗总有效率93.33%高于对照组73.33%(P<0.05);治疗前两组MMSE评分、ADL评分比较无统计学差异(P>0.05),治疗后观察组MMSE评分及ADL评分高于对照组(P<0.05)。结论培元通脑胶囊联合尼莫地平治疗PD效果显著,可有效改善患者认知功能、提高生活自理能力。

Objective To explore the application value of Pei Yuan Tong Nao capsule combined with nimodipine in patients with Parkinson's disease(PD).Methods From May 2016 to February 2018,60PD patients in our hospital were randomly divided into the observation group and the control group,30cases in each group.On the basis of conventional anti Parkinson disease treatment,the control group was treated with nimodipine and the observation group was treated with nimodipine+Pei Yuan Tong Nao capsule for 12 weeks.The clinical efficacy,cognitive function(MMSE score)and daily life self-care ability(ADL score)were compared between the two groups.Results The total effective rate of the observation group was 93.33%(28/30),higher than that of the control group 73.33%(22/30)(P<0.05).There was insignificant difference in MMSE score and ADL score between the two groups before treatment(P>0.05).After treatment,the MMSE score and ADL score of the observation group were higher than those of the control group(P<0.05).Conclusion Pei Yuan Tong Nao capsule combined with nimodipine is effective in treating PD,which can effectively improve the cognitive function and improve the self-care ability of patients.