中药熏蒸联合局部按摩治疗睑板腺功能障碍的效果分析

Effect of herbal fumigation combined with local massage in the treatment of meibomian gland dysfunction

目的:评估中药熏蒸联合局部按摩治疗睑板腺功能障碍(MGD)的临床疗效。方法:选取MGD病人66例(132眼),随机分为观察组和对照组,每组33例(66眼)。对照组给予人工泪液、抗炎滴眼液治疗为主,对于疑似感染或三级以上MGD病人另外加服阿奇霉素;观察组在此基础上施以中药熏蒸联合睑板腺按摩治疗。治疗4周后,观察、记录并比较2组病人眼表疾病指数(OSDI)、泪膜破裂时间(TBUT)、泪液分泌试验(SIT)、角膜荧光素染色(CFS)以及睑板腺功能的变化。结果:观察组OSDI分值、睑板腺功能异常评分、CFS积分均低于对照组,TBUT和SIT值均高于对照组(P<0.01)。2组疗效差异有统计学意义(P<0.01)。结论:中药熏蒸联合局部按摩可提高MGD治疗的临床疗效。

Objective: To evaluate the clinical effectiveness of herbal fumigation combined with local massage in the treatment of meibomian gland dysfunction( MGD).Methods: One hundred and thirty-two eyes( 66 patients) with MGD were randomly divided into the observation group and control group( 66 eyes in 33 patients each group).The control group was treated with artificial tear and antibiotic eye drops,and the patients suspected by infection or grade 3 or above MGD were additionally treated with azithromycin by oral.The observation group was treated with herbal fumigation combined with meibomian gland massage based on the artificial tear and antibiotic eye drops.After 4 weeks of treatment,the ocular surface disease index( OSDI),tear film breakup time( TBUT),Schirmer I test( SIT),corneal fluorescein staining( CFS),and meibomian gland function were observed and analyzed in two groups.Results: The scores of OSDI,MGD and CFS in observation group were lower than those in control group,and the scores of TBUT and SIT in observation group were higher than those in control group( P < 0.01).The difference of the clinical effectiveness between two groups was statistically significant( P < 0.01).Conclusions: The herbal fumigation combined with local massage can improve the curative effect of MGD treatment.