重组人干扰素α2b凝胶治疗小儿手足口病的临床研究

Clinical Study of Recombinant Human Interferon α2b Gel in the Treatment of Hand, Foot and Mouth Disease in Children

目的:探讨重组人干扰素α2b凝胶治疗小儿手足口病的临床效果。方法:择取2017年1月~2018年12月期间某院收治的92例患儿,随机分为对照组与观察组,每组46例。对照组患儿行喜炎平治疗,观察组患儿行喜炎平联合干扰素α2b凝胶治疗,比较两组临床疗效、临床症状消退时间和住院时间。结果:观察组患儿临床疗效高于对照组,差异有统计学意义(P<0.05);观察组患儿临床症状消退时间和住院时间均少于对照组,差异有统计学意义(P<0.05)。结论:重组人干扰素α2b凝胶外涂治疗小儿手足口病具有确切的临床疗效,可有效促进患儿临床症状消失,缩短其住院时间,对患儿康复具有积极影响,因此该种治疗方案值得在临床中进行推广应用。

Objective: To investigate the clinical effect of recombinant human interferon α 2b gel in the treatment of hand, foot and mouth disease in children. Methods: From January 2017 to December 2018, 92 children treated in a hospital were selected and randomly divided into control group and observation group,with 46 patients in each group. The control group was treated with Xiyanping, and the observation group was treated with Xiyanping combined with interferon α2b gel.The clinical efficacy, clinical symptoms and hospitalization time were compared between the two groups. Results: The clinical efficacy of the observation group was higher than that of the control group,and the difference was statistically significant ( P <0.05). The clinical symptom regression time and hospitalization time were lower in the observation group than in the control group,and the difference was statistically significant ( P <0.05). Conclusion: Recombinant human interferon α2b gel coating has a definite clinical effect in the treatment of hand, foot and mouth disease in children. It can effectively promote the disappearance of clinical symptoms, shorten the length of hospital stay, and have a positive impact on the rehabilitation of children. Therefore, this treatment scheme is worth popularizing and applying in clinical practice.