多烯磷脂酰胆碱联合二甲双胍治疗非酒精性脂肪肝临床疗效及其对肝功能指标情况观察

Efficacy and Safety of Metformin in the Treatment of Nonalcoholic Fatty Liver Disease

目的:探讨二甲双胍辅助治疗非酒精性脂肪肝的可行性及安全性。方法:选取2014年4月~2016年4月某院接诊的76例非酒精性脂肪肝患者,随机均分为两组。对照组用多烯磷脂酰胆碱治疗,观察组用多烯磷脂酰胆碱联合二甲双胍治疗,比较两组患者治疗前后的肝功能指标和血脂指标(ALT、AST、TG、TC水平),并评价两组的临床治疗效果。结果:治疗后,两组的ALT、AST、TG、TC水平均显著降低(P<0.05),且观察组的ALT、AST、TG、TC水平显著低于对照组,差异有统计学意义(P<0.05);观察组患者总有效率为94.7%,对照组患者总有效率为73.7%,研究组明显高于对照组(χ^2=7.3620,P=0.0004)。结论:采用二甲双胍(联合多烯磷脂酰胆碱)辅助治疗非酒精性脂肪肝,可显著改善肝功能,降低血脂水平,可行性高,安全性好,值得推广应用。

Objective: To investigate the feasibility and safety of metformin in the treatment of nonalcoholic fatty liver disease. Methods: 76 cases of patients with nonalcoholic fatty liver in a hospital from April 2014 to April 2016 were randomly divided into two groups. The control group was treated with polyene phosphatidyl choline, and the observation group was treated with polyene phosphatidylcholine combined with metformin. The liver function indexes and blood lipid indexes (ALT, AST, TG, TC) were compared between the two groups before and after treatment, and the clinical therapeutic effects of the two groups were evaluated. Results: After treatment, the ALT, AST, TG and TC levels of the two groups were significantly decreased ( P <0.05), and the ALT, AST, TG and TC of the observation group were significantly lower than the control group, the difference was statistically significant ( P <0.05). The observation group of patients with the total effective rate was 94.7%, the total effective rate of control group was 73.7%, the study group was significantly higher than the control group (χ^ 2 =7.3620, P =0.0004). Conclusion: The treatment of nonalcoholic fatty liver disease with metformin combined with polyene phosphatidyl choline can signifi-cantly improve liver function and reduce blood lipid level, with high feasibility, good safety, worthy of popularization and application.