硫普罗宁的临床应用及药理作用探讨

Clinical Application and Pharmacological Action of Tiopronin

目的:对硫普罗宁的药理作用进行探讨,同时对硫普罗宁的临床疗效进行调查。方法:随机抽取某院58例抗结核治疗造成肝损害的患者,所有人员均为2017年3月~2018年3月间入院治疗人员。在系统随机分组条件下分为干预组和对照组各29例,干预组在对照组的基础上予以硫普罗宁治疗,比较患者治疗效果,同时比较患者治疗后不良反应发生率。结果:干预组患者治疗后谷丙转氨酶水平为(54.8±11.6)U/L,对照组为(81.5±13.7)U/L;干预组患者治疗后谷草转氨酶水平为(43.6±5.7)U/L,对照组为(71.9±14.7)U/L,P<0.05。干预组患者疗效评估有效率为93.1%,对照组为81.5%,P<0.05;干预组1例恶心病例,对照组1例呕吐病例,发生率均为3.4%,P>0.05,不具备统计学意义。结论:硫普罗宁在抗结核治疗造成肝损害患者中的治疗效果很理想。

Objective: To investigate the pharmacological effects of tiopronin and to investigate the clinical efficacy of tiopronin. Methods: 58 patients with liver damage caused by anti tuberculosis treatment in a hospital were randomly selected, all of whom were hospitalized from March 2017 to March 2018. Under the condition of systematic random grouping, the patients were divided into intervention group and control group, with 29 cases each. The intervention group was treated with tiopronin on the basis of the control group, and the therapeutic effect was compared, and the incidence of adverse reactions after treatment was compared. Results: The level of alanine transaminase in the intervention group was (54.8±11.6) U/L and the control group was (81.5±13.7) U/L, and the level of transaminase of cereal grass in the intervention group was (43.6±5.7) U/L, the control group was (71.9±14.7) U/L, P < 0.05. The effective rate of the intervention group was 93.1%, while that of the control group was 81.5%, P <0.05. There were 1 nausea cases in the intervention group and 1 vomiting cases in the control group. The incidence rates were 3.4%, P >0.05, and there was no statistical significance. Conclusion: Tiopronin is effective in the treatment of liver damage caused by anti tuberculosis treatment.