阿托伐他汀对急性心肌梗死患者PCI术后左室重构、血脂的影响观察

Effects of Atorvastatin on Left Ventricular Remodeling and Blood Lipids in Patients with Acute Myocardial Infarction after PCI Operation

目的:探讨阿托伐他汀对急性心肌梗死患者经皮冠状动脉介入术(Percutaneouscoronaryintervention,PCI)术后左室重构、血脂等指标的改善效果。方法:回顾性分析2016年6月~2018年9月在某院治疗的150例急性心肌梗死患者的临床资料,所有患者均已接受阿托伐他汀治疗,并于治疗前、治疗后1个月、3个月与6个月,接受心脏彩超、血脂等一系列检查,比较治疗前与治疗后6个月患者左室重构[左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)]、血脂指标[血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)]。结果:治疗后6个月,患者LVEDD低于治疗前,LVEF高于治疗前,差异有统计学意义(P<0.05);治疗后6个月,患者TC、TG、LDL-C水平均低于治疗前,HDL-C水平高于治疗前,差异有统计学意义(P<0.05)。结论:急性心肌梗死患者经阿托伐他汀序贯治疗后,可有效改善PCI术后左室重构,利于调节血脂水平。

Objective: To explore the improvement effects of atorvastatin on left ventricular remodeling and blood lipids in patients with acute myocardial infarction after percutaneous coronary intervention (PCI). Methods: The clinical data of 150 patients with acute myocardial infarction treated in a hospital from June 2016 to September 2018 were retrospectively analyzed. All patients were treated with atorvastatin, and given a series of examinations such as cardiac ultrasound and blood lipids before treatment and at 1 month, 3 months and 6 months after treatment. The left ventricular remodeling [left ventricular end diastolic diamete (LVEDD), left Left ventricular ejection function (LVEF)] and blood lipids indexes [serum total cholesterol (TC), triglyceride (TG), high density lipid-cholesterol (HDL-C), low density lipid-cholesterol (LDL-C)] were compared before treatment and at 6 months after treatment. Results: At 6 months after treatment, the LVEDD was lower than that before treatment while the LVEF was higher than that before treatment, and the difference was statistically significant ( P <0.05). At 6 months after treatment, the levels of TC, TG and LDL-C were lower than those before treatment while the HDL-C level was higher than that before treatment,and the differences were statistically significant ( P <0.05). Conclusion: Sequential therapy of atorvastatin for patients with acute myocardial infarction can improve the left ventricular remodeling after PCI, and it is beneficial to regulate blood lipids levels.