摘要
目的评价临床药师开展的药学服务对华法林抗凝治疗质量的影响及产生的效果。方法 2016. 9~2017. 9期间临床药师纳入我院血管外科及心内科因血栓栓塞性疾病的预防或治疗而需要口服华法林抗凝治疗的患者,按设定的药学服务流程进行管理及随访,同时调取我院信息系统中2013. 7~2015. 7期间服用华法林的患者作为基线对照组,记录两组患者的INR(国际标准化比值)变化情况、华法林稳态剂量、达稳态时间等,并计算患者的TTR(达标时间百分比),对两组的指标变化情况进行统计分析。结果与对照组相比,临床药师干预的患者TTR明显升高[(63. 65±32. 00)%vs.(50. 80±22. 32)%,P=0. 003],高质量抗凝治疗的患者比例明显提高(47. 89%vs. 20. 09%,P <0. 001),达稳态时间明显缩短[(22. 81±14. 91) vs.(46. 14±80. 79),P=0. 003],INR监测次数明显增多[(11. 7±4. 8) vs.(6. 0±3. 5),P <0. 001];药师用药教育后患者的抗凝认知评分较用药教育前大幅升高[(16. 78±0. 92) vs.(6. 93±3. 77),P <0. 001]。结论临床药师参与抗凝药物治疗管理可显著改善患者华法林抗凝治疗的质量。
OBJECTIVE To evaluate the effects of clinical pharmacy services in patients with warfarin and highlight the important role of clinical pharmacists. METHODS Patients in need of warfarin were enrolled as intervention group during 2016. 9-2017. 9 to receive standard anticoagulation management and follow-up provided by clinical pharmacists,and clinical data of patients who meet the inclusion criteria during 2013. 7-2015. 7 as control group was analyzed retrospectively. International normalized ratio( INR) values,maintenance doses,time to achieve therapeutic range,and etc. were recorded and TTRs( time in therapeutic range) were calculated to compare the outcomes of each group. RESULTS TTRs in intervention group were significantly higher than those in control group[( 63. 65 ± 32. 00) % vs.( 50. 80 ± 22. 32) %,P = 0. 003],and so was the percentage of patients with the best quality of warfarin therapy( 47. 89% vs. 20. 09%,P < 0. 001). Time to achieve therapeutic range was shorter[( 22. 81 ± 14. 91) vs.( 46. 14 ± 80. 79),P = 0. 003] and the frequency of INR test was higher [( 11. 7 ± 4. 8) vs.( 6. 0 ± 3. 5),P < 0. 001] in intervention group compared with those in control group. Patients’ cognitive scores of warfarin therapy were substantially increased after pharmacist’ s education[( 16. 78 ± 0. 92) vs.( 6. 93 ± 3. 77),P < 0. 001]. CONCLUSION Anticoagulation therapy management provided by clinical pharmacists could significantly improve the quality of warfarin therapy.
作者
都丽萍
李莹
李玲玲
保芸
尤国皎
任爽
张波
梅丹
DU Li-ping;LI Ying;LI Ling-ling;BAO Yun;YOU Guo-jiao;REN Shuang;ZHANG Bo;MEI Dan(Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;Department of Pharmacy, Gansu Provincial Hospital, Lanzhou 730000, China;Department of Pharmacy, Air Force Medical University Xijing Hospital, Xi′an 710032, China;Department of Pharmacy,Beijing Jishuitan Hospital,Beijing 100035, China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2019年第9期749-752,共4页
Chinese Pharmaceutical Journal
基金
北京药学会临床药学研究项目资助
关键词
临床药师
华法林
达标时间百分比
抗凝治疗管理
clinical pharmacist
warfarin
time in therapeutic range
anticoagulation therapy management