壮药珠芽艾麻化学成分研究

Chemical Constituents from Laportea bulbifera,a Zhuang Medicine

目的研究壮药珠芽艾麻(Laportea bulbifera)的化学成分。方法珠芽艾麻用体积分数60%乙醇提取,经硅胶、聚酰胺、Sephadex LH-20、ODS、重结晶、半制备HPLC进行分离纯化。结合理化性质、波谱数据鉴定化合物的结构。结果从中分离出10个化合物,分别鉴定为β-谷甾醇(1),原儿茶酸乙酯(2),东莨菪亭(3),反式肉桂酸(4),(E)-对羟基肉桂酸(5),山柰酚-7-O-α-L-鼠李糖苷(6),木犀草素(7),没食子酸乙酯(8),(+)-异落叶松脂素-9-O-β-D吡喃葡萄糖(9)和山柰酚-3,7-α-L-二鼠李糖苷(10)。结论化合物2,5,7~9为首次从艾麻属植物中分离得到,化合物2~5,7~9为首次从该植物中分离得到。

OBJECTIVE To study the chemical constituents from Laportea bulbifera. METHODS The 60% ethanol extract from L. bulbifera was isolated and purified by chromatography on silica, Sephadex LH-20, and ODS, recrystallization, and semi-preparative HPLC. Their chemical structures were elucidated by physicochemical properties and spectroscopic methods. RESULTS These compounds were determined as β-sitosterol(1), protocatechuic acid ethyl ester(2), scopoletin (3), trans-cinnamic acid (4),trans-p-hydroxycinnamic acid(5), kaempferol 7-O-rhamnoside(6), luteolin(7), ethyl gallate(8),(+)-isolarisiresinol 3a-O-β-D-glucopyranoside(9), and kaempferitrin(10). CONCLUSION Compounds 2, 5, 7-9 are isolated from genus Laportea for the first time, and compounds 2-5,7-9 are isolated from this plant for the first time.