抗肝癌Ⅰ号方改善早、中期原发性肝细胞癌患者生活质量的临床研究

Clinical study on improving the quality of life in patients with early and middle stages hepatocellular carcinoma

目的探究抗肝癌Ⅰ号方对早、中期原发性肝细胞癌患者生活质量改善情况。方法纳入早、中期原发性肝细胞癌患者36例,口服抗肝癌Ⅰ号方,连续治疗6个月。于治疗前、治疗3个月和治疗6个月时观察患者生活质量、中医证候改善情况。结果①生活质量评分比较:肝癌患者在口服抗肝癌Ⅰ号方治疗期间,躯体功能、角色功能、情绪功能、认知功能、社会功能、总健康状况、疲倦、疼痛、气促、失眠、食欲丧失、便秘、腹泻评分持续改善,差异具有统计学意义(P <0. 05)。②中医证候评分比较:中医证候量化总积分在治疗期间持续降低(P <0. 05)。肝癌患者胁痛、胸闷善太息、食少、脘闷、情绪抑郁、嗳气、腹胀、面色晦暗、大便干结、口黏不欲饮、心烦、易怒、口苦、口干咽燥、溲赤、烦渴、耳鸣、膝软、失眠症状积分在治疗期间持续降低(P <0. 05)。结论初步观察到抗肝癌Ⅰ号方能够提高早、中期原发性肝细胞癌患者生活质量、缓解临床症状,且长期服药效果较短期服药效果好。

Objective To observe the improvements of life quality of the patients with the early and middle stages hepatocellular carcinoma after treatment by using No.1 Anti Liver Cancer Prescription.Methods Thirty-six patients with early and middle stages hepatocellular carcinoma were included in this study.The patients took No.1 Anti Liver Cancer Prescription orally for 6 months continuously.The medical indicators including the quality of life and traditional Chinese medicine(TCM)syndromes were measured and recorded before the treatment,at the 3nd month of the treatment and at the end of the treatment.Results①Comparison of quality of life scores:The scores of physical function,role function,emotional function,cognitive function,social function,general health status,fatigue,pain,shortness of breath,insomnia,loss of appetite,constipation and diarrhea were improved continuously.The difference was statistically significant(P<0.05).②Comparison of TCM syndromes scores:Total score of TCM syndromes was decreased during the treatment period(P<0.05).The syndrome scores of hypochondriac pain,chest tightness and easy to sigh,loss of food-intake,stomach bilges,depressed,belching,abdominal distension,gloomy complexion,dry stool,mouth stick without desire to drink,upset,irritability,bitter taste,mouth and pharyngeal dry,yellow urine,polydipsia,tinnitus,knee weakness,and insomnia were decreased during the treatment period(P<0.05).Conclusion Preliminary observation,No.1 Anti Liver Cancer Prescription was able to improve the quality of life of patients with early and middle stages hepatocellular carcinoma.It can also alleviate clinical symptoms.The meditation effect of long-term treatment is better than that of short-term treatment.