肠道微生态与银屑病的中医研究

The traditional Chinese medicine in the treatment of gut microbiota and psoriasis

银屑病是一种常见的以慢性炎性反应为特征的全身心身疾病,与肠道菌群紊乱密切相关。中医的整体观和恒动观与肠道微生态的整体性、动态性特征相契合;“肺与大肠相表里”、“肺主皮毛”、“肠-脑-皮轴”学说,及已有有关中医药维持肠道微生态稳态的研究,为从肠道微生态角度探索银屑病的中医诊治机制提供了依据。将传统中医证候与客观的微生态学相结合,明确不同中医证型肠道微生态的特征性变化,探究可调节此类肠道微生态失调的中药复方制剂或单味药物,通过肠道菌群与中医“方”和“证”结合研究以寻找中医药治疗银屑病的新思路及新方法。

Psoriasis is a common systemic psychosomatic disorder characterized with immune-mediated chronic relapsing-remitting inflammation,which is closely related to intestinal flora dermatosis.The integrity and dynamic characteristics of the intestinal micro-ecology are consistent with the holistic view and perpetual motion view in traditional Chinese medicine(TCM).Some theories such as“The lung and the large intestine are interior-exteriorly related”,“Lung relating to skin theory”and“Gut-brain-skin axis theory”,and some researches on TCM maintaining the balance of intestinal microecology,provide a basis for exploring the TCM mechanism of diagnosis and treatment of psoriasis from the perspective of intestinal microecology.Based on a review of modern medical research on intestinal flora disorders and psoriasis vulgaris,this article interpreted the theories of TCM researches on intestinal flora of psoriasis,and explored the regulation function of intestinal microflora in TCM prevention and treatment of psoriasis.The new thought of TCM treating psoriasis by regulating intestinal microecology was proposed.