microRNA-181b对心血管疾病的调控作用及机制的研究进展

Research advances on the regulation and mechanism of microRNA-181b on cardiovascular diseases

心血管疾病是当前发病率和病死率最高的疾病之一。microRNA-181b(miR-181b)在心血管疾病的发生和发展过程中发挥了重要的作用。大量研究表明,miR-181b可通过调控心血管组织中的相关靶基因进而调节细胞因子、蛋白酶以及受体的表达,从而参与调控心血管系统的生理及病理状态。在高血压、动脉粥样硬化、动脉瓣膜钙化、心肌纤维化、心肌肥厚以及心肌炎等心血管疾病中发挥着重要的调控作用。本文拟就相关的研究进展对miR-181b在心血管疾病中的作用及机制进行综述。

Cardiovascular disease is one of the diseases with the highest morbidity and mortality.Numerous studies have shown that microRNA181b(miR-181b)can regulate the physiological and pathological state of the cardiovascular system by regulating the relevant target genes in cardiovascular tissues and regulating the expression of cytokines,proteases and receptors.It plays an important regulatory role in cardiovascular diseases such as hypertension,atherosclerosis,arterial valve calcification,myocardial fibrosis,cardiac hypertrophy and myocarditis.This article reviewed the research progresses on the role and mechanism of miR-181b in cardiovascular disease.