18F-FDG PET/CT对大白兔肿瘤及炎症模型血流量及代谢分析的初步研究

Evaluation of Blood Flow and Metabolismin Rabbit Tumor and Inflammation Models with 18F-FDG PET/CT:a Pilot Study

目的采用18F-脱氧葡萄糖(FDG) PET/CT比较大白兔肿瘤及炎症血流量及代谢的差异。方法 6只新西兰大白兔前肢种植VX2瘤及炎症模型,分别进行18F-FDG PET/CT动态显像,获得肿瘤及炎症模型的动态图像,采用首次通过法计算血流量,并计算肿瘤的最大标准摄取值(SUVmax)。结果肿瘤模型血流量为(15.08± 4.36)mL·min^-1·(100 g)^-1、SUVmax值为(2.25±0.24),炎症模型分别为(10.84±2.70)mL·min^-1·(100 g)^-1、(1.72±0.23),肿瘤模型血流量、SUVmax值均明显高于炎症模型( P <0.05)。结论采用FDG/CT显像可以同时获得血流量及代谢参数,初步结果表明,肿瘤模型的血流量及代谢均高于炎症模型,有可能成为鉴别恶性病变与炎性病变的指标。

Objective To compare the blood flow and metabolism between rabbit tumor and inflammation models with18F-FDG PET/CT. Methods Dynamic 18F-FDG PET/CT imaging were performed in six New Zealand white rabbits bearing VX2 tumors and inflammatory lesions in forelimbs.The first-pass blood flow and maximum standardized uptake value(SUVmax) were calculated. Results Compared with inflammatory lesions,both blood flow and SUVmax significantly increased in tumors [(15.08±4.36)mL·min^-1·(100 g)^-1 vs (10.84±2.70)mL·min^-1·(100 g)^-1 and (2.25±0.24) vs (1.72±0.23),respectively]( P <0.05). Conclusion The parameters of blood flow and metabolism can be obtained simultaneously by18F-FDG PET.Our results suggest that both blood flow and metabolism in tumors are higher than those in inflammatory lesions.Therefore,blood flow and metabolism may be the potential indicators to distinguish malignant lesions from inflammatory lesions.