盐酸氨溴索在慢性支气管炎治疗中的疗效与安全性观察

Efficacy and safety of Ambroxol hydrochloride in treatment of chronic bronchitis

目的:观察盐酸氨溴索在慢性支气管炎治疗中的疗效与安全性。方法:选取84例慢性支气管炎患者为研究对象,按照就诊顺序随机分为对照组40例与观察组44例,对照组给予常规治疗,观察组在对照组基础上给予盐酸氨溴索静脉滴注治疗,对比两组患者临床总有效率、症状消失时间、住院治疗时间、治疗前后肺功能改善情况及不良反应发生率。结果:观察组临床治疗总有效率为100.00%,高于对照组的85.00%,差异有统计学意义(P<0.05)。观察组症状消失时间及住院治疗时间均显著短于对照组,差异有统计学意义(P<0.05)。两组患者治疗前肺功能指标比较,差异无统计学意义(P>0.05);治疗后观察组FVC、FEV1、PEF改善情况均优于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为6.82%,对照组为12.50%,两组比较差异无统计学意义(P>0.05)。结论:慢性支气管炎的治疗中应用盐酸氨溴索雾化吸入可有效提高患者临床疗效,加快症状的缓解,缩短患者住院治疗时间,且安全性高。

Objective: To explore efficacy and safety of Ambroxol hydrochloride in treatment of chronic bronchitis. Methods: 84 patients with chronic bronchitis were selected as the subjects. According to the order of treatment, they were divided into the control group(n=40) and observation group(n=44). The control group was given conventional treatment, while the observation group was intravenously dripped with Ambroxol hydrochloride on the basis of that of the control group. The total effective rate, symptom disappearance time, hospitalization time, improvement of lung function before and after the treatment, and incidence of adverse reactions were compared between the two groups. Results: The total effective rate in the observation group was 100.00%, which was higher than that of the control group(85.00%), and the difference was statistically significant(P<0.05). The symptom disappearance time and hospitalization time of the observation group were significantly shorter than those of the control group, and the differences were statistically significant(P<0.05). There was no significant difference in the preoperative lung function between the two groups(P>0.05);however, after the treatment, the improvements of FVC, FEV1 and PEF in the observation group were better than those in the control group(P<0.05), and the differences were statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 6.82%, which was lower than that of the control group(12.50%), and the difference was statistically significant(P<0.05). Conclusions: Ambroxol hydrochloride aerosol inhalation in the treatment of chronic bronchitis can effectively improve the clinical efficacy of the patients, accelerate the relief of the symptoms, and shorten the hospitalization time with high safety.