曲普瑞林对子宫内膜异位症腹腔镜术后氧化应激状态及复发率的影响

Effects of Triptorelin on oxidative stress status and recurrence rate in patients with endometriosis after laparoscopic surgeries

目的:观察曲普瑞林对子宫内膜异位症(EM)腹腔镜术后氧化应激状态及复发率的影响。方法:收集2014年5月至2017年4月96例子宫内膜异位症患者,按随机数字表法分为观察组与对照组各48例。两组均接受腹腔镜手术治疗,术后,对照组口服孕三烯酮治疗,观察组肌内注射曲普瑞林治疗,疗程均为12周。比较两组疗效、治疗前后氧化应激状态及复发情况。结果:观察组治疗总有效率明显高于对照组,差异有统计学意义(95.83%VS 81.25,P<0.05)。治疗后,两组ROS、MDA水平均较治疗前明显降低,且观察组明显低于对照组;两组SOD、GSH-Px水平均较治疗前明显升高,且观察组明显高于对照组(P<0.05)。观察组不良反应明显低于对照组(P<0.05)。观察组1年复发率为4.17%,明显低于对照组的16.67%(P<0.05)。结论:曲普瑞林有利于改善EM患者腹腔镜手术疗效,还能降低患者氧化应激水平和复发率,不良反应较少。

Objective: To observe effects of Triptorelin on oxidative stress status and recurrence rate in patients with endometriosis(EM) after laparoscopic surgeries. Methods: 96 patients with EM were collected from May 2014 to April 2017 and divided into observation group and control group according to the random number table method, 48 cases in each. Both groups underwent the laparoscopic surgeries. After the operation, the control group received oral Gestrinone treatment for 12 weeks, while the observation group received intramuscular injection of Triptorelin for 12 weeks. The efficacy, oxidative stress status and recurrence were compared between the two groups. Results: The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant(95.83% vs 81.25, P<0.05). After the treatment, the levels of ROS and MDA in the two groups were lower than those before the treatment, and those of the observation group were lower than those of the control group. After the treatment, the levels of SOD and GSH-Px in the two groups were higher than those before the treatment, and those of the observation group were higher than those of the control group(P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05). Further, the 1-year recurrence rate of the observation group was 4.17%, which was lower than that of the control group of 16.67%(P<0.05). Conclusions: Triptorelin is beneficial to improve the efficacy of the laparoscopic surgery in the patients with EM, and can also reduce the oxidative stress level and recurrence rate with fewer adverse reactions.