1～2枚前哨淋巴结阳性乳腺浸润性导管癌患者非前哨淋巴结转移与临床特征的关系

Relationship between non-sentinel lymph node metastasis and the clinical characteristics in breast invasive ductal carcinoma patients with 1-2 positive sentinel lymph nodes

目的探讨1~2枚前哨淋巴结(SLN)阳性的乳腺浸润性导管癌患者非前哨淋巴(NSLN)转移与临床特征的关系。方法收集58例接受SLN活检术,病理提示SLN转移1~2枚,并进一步接受腋窝淋巴结清扫术的乳腺浸润性导管癌患者,分析并比较不同临床特征患者的NSLN阳性率。结果58例1~2枚SLN阳性乳腺癌患者中,30例(51.7%)患者NSLN阴性,28例(48.3%)患者NSLN阳性。SLN阳性/总SLN≥0.5的患者NSLN阳性率高于SLN阳性/总SLN<0.5的患者,差异有统计学意义(P<0.05)。不同年龄、月经状态、肿瘤最大径、脉管瘤栓、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER2)、Ki-67、SLN阳性数的乳腺癌患者的NSLN阳性率比较,差异均无统计学意义(P﹥0.05)。结论1~2枚SLN阳性的乳腺浸润性导管癌患者仍然存在NSLN阳性风险,SLN阳性/总SLN≥0.5时,NSLN阳性率较高。

Objective To investigate the relationship between non-sentinel lymph node(NSLN)metastasis and the clinical characteristics in breast invasive ductal carcinoma patients with 1-2 positive sentinel lymph nodes(SLN).Method Fifty-eight patients with breast invasive ductal carcinoma who underwent sentinel lymph node biopsy(SLNB),with 1 to 2 positive metastatic SLN,followed by axillary lymph node dissection were included in the study,the positive rate of NSLN among patients with different clinical characteristics were compared.Result Among the 58 cases with 1-2 positive SLN,NSLN were negative in 30 cases(51.7%)and positive in 28 cases(48.3%).The positive rate of NSLN in patients with ratio of positive SLN/overall SLN≥0.5 was significantly higher compared to those with positive SLN/overall SLN<0.5,and the difference was of statistical significance(P<0.05).There was no evident difference regarding the positive rate of NSLN among patients with different age,menopausal status,maximum tumor diameter,intravascular tumor emboli,expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER2),Ki-67,and number of positive SLN(P>0.05).Conclusion The risk of positive NSLN still exists for breast invasive ductal carcinoma patients with 1 to 2 positive SLN,besides,the positive rate of NSLN is significantly higher when the ratio of positive SLN/overall SLN≥0.5.