急性发热患者EB病毒检测结果分析

Analysis of detection results of EB virus in patients with acute fever

目的通过检测热性疾病患者的EB病毒的感染情况及病毒载量,探讨EB病毒检测对于不同年龄、不同症状发热患者的诊断意义。方法利用病原体监测法研究2016年1月1日至2017年4月18日于内蒙古医科大学附属医院就诊的热性疾病患者(n=1 858)的EB病毒感染情况及病毒载量。结果男性EB病毒感染率高于女性(P<0.05)。随着年龄的增长,EB病毒的感染率呈现先增高再降低又增高的趋势。发热伴传染性单核细胞增多症患者的EB病毒感染率最高,将其作为对照,通过比较分析可以发现,单一急性发热症状、发热伴惊厥抽搐症状患者的EB病毒感染率亦较高,其与发热伴传染性单核细胞增多症患者的EB病毒感染率比较,差异无统计学意义(P>0.05);发热伴支气管炎、上呼吸道感染、肺炎、淋巴结肿大、呕吐、腹泻、血小板减少症及头晕、头痛、嗜睡患者的EB病毒感染率显著低于发热伴传染性单核细胞增多症患者(P<0.05)。结论不同年龄阶段的急性发热患者中EB病毒阳性检出率均较高,检测EB病毒感染情况对于急性发热与呕吐、腹泻、惊厥、抽搐伴发热症状的患者具有显著的诊断意义。

Objective To explore the diagnostic significance of EB virus detection for fever patients of different ages and symptoms by detecting the infection and viral load of EB virus in patients with febrile diseases. Methods The EB virus infection and viral load in patients with febrile diseases (n=1 858) who visited Affiliated Hospital of Inner Mongolia Medical University from January 1, 2016 to April 18, 2017 were studied by pathogen monitoring method. Results The infection rate of EB virus in males was higher than that in females (P<0.05). With the increase of age, the infection rate of EB virus shows a trend of first increased, then decreased and then increased. EB virus infection rate was the highest in fever patients with infectious mononucleosis, use it as a control group, it can be found through comparative analysis that the patients with single acute fever, fever with convulsions and hyperspasmia also had higher infection rates of EB virus, and there were no significant differences in the infection rate of EB virus between the patients with fever and mononucleosis (P>0.05). The infection rates of EB virus in patients with fever and bronchitis, upper respiratory tract infection, pneumonia, lymphadenopathy, vomiting, diarrhea, thrombocytopenia and dizziness, headache, sleepiness were significantly lower than that in patients with fever and mononucleosis (P<0.05). Conclusion The positive rate of EB virus was high in patients with acute fever at different age stages. Detection of EB virus infection has significant diagnostic significance for patients with acute fever and vomiting, diarrhea, convulsions, convulsions and fever symptoms.