针刺坐骨神经干对坐骨神经痛患者MCP-1及炎性因子水平的影响

Effect of acupuncture of sciatic nerve trunk on MCP-1 and inflammatory factor levels in patients with sciatic neuralgia

目的探究针刺坐骨神经干治疗坐骨神经痛患者的临床效果及对单核细胞趋化蛋白-1(MCP-1)及炎性因子水平的影响,为相关研究提供临床指导。方法选取2017年1月至2018年1月在我院接受治疗的200例坐骨神经痛患者作为研究对象,根据数字单双号法将其分为对照组(n=84)和观察组(n=116)。对照组采用常规西医治疗,观察组在对照组的基础上采取中医坐骨神经干针刺法。比较两组的临床治疗效果、疼痛分级指数(PRI)、视觉模拟评分法(VAS)、现有疼痛强度(PPI)评分、MCP-1、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。结果治疗后,观察组临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组的PRI、VAS、PPI评分比较,差异无统计学意义(P>0.05);治疗后,两组的PRI、VAS、PPI评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组的MCP-1、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,两组的MCP-1、IL-6、TNF-α水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论针刺坐骨神经干治疗坐骨神经痛患者效果显著,有利于减轻患者的疼痛,降低MCP-1水平,抑制相关炎性因子的表达,值得临床推广应用。

Objective To explore the clinical effect of acupuncture of sciatic nerve trunk in patients with sciatic neuralgia and the influence on the levels of monocyte chemoattractant protein-1(MCP-1) and inflammatory factors, so as to provide clinical guidance for related research. Methods A total of 200 patients with sciatica neuralgia treated in our hospital from January 2017 to January 2018 were selected as the study objects and divided into control group(n=84) and observation group(n =116) according to digital odd and even number method. The control group was treated with conventional western medicine, while the observation group was treated with traditional Chinese medicine acupuncture of sciatic nerve trunk on the basis of the control group. The clinical treatment effects, the scores of pain rating index(PRI),visual analogue scale(VAS), present pain intensity(PPI), levels of MCP-1, interleukin 6(IL-6) and tumor necrosis factor-α(TNF-α) of the two groups were compared. Results After treatment, the total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). Before treatment, there were no significant differences in the scores of PRI,VAS and PPI between the two groups(P>0.05);after treatment, the scores of PRI, VAS and PPI in the two groups decreased,and those in the observation group were lower than the control group, the differences were statistically significant(P<0.05).Before treatment, there were no significant differences in the levels of MCP-1, IL-6 and TNF-α between the two groups(P>0.05);after treatment, the levels of MCP-1, IL-6 and TNF-α in the two groups decreased, and those in the observation group were lower than the control group, the differences were statistically significant(P<0.05). Conclusion Acupuncture of sciatic nerve trunk has remarkable therapeutic effect on patients with sciatic neuralgia, it is helpful to relieve pain, reduce the level of MCP-1 and inhibit the expression of inflammatory factors, which is worthy of clinical promotion and application.