联合检测尿液中Survivin和MUC7在膀胱癌诊断中的临床应用

Clinical significance of combined detection of Survivin and MUC7 in urine in the detection of bladder cancer

目的探讨检测尿液中Survivin和mucin7(MUC7)在诊断膀胱癌中的临床价值。方法对75例膀胱肿瘤患者、38例泌尿系统良性疾病患者及20例健康自愿者在行膀胱镜检前分别留置3份尿液标本,通过检测尿液中Survivin、MUC7和尿脱落细胞学的敏感性和特异性,分析比较3种方法在临床诊断膀胱癌的临床应用价值。结果Survivin诊断膀胱癌的敏感性和特异性分别是93.3%和98.3%,MUC7诊断膀胱癌的敏感性和特异性分别是80%和100%;尿脱落细胞学诊断膀胱癌的敏感性和特异性分别是66.7%和100%;Survivin联合MUC7的敏感性和特异性分别是98.7%和100%;Survivin联合MUC7、Survivin、MUC7与尿脱落细胞学的敏感性比较差异均有统计学意义(P<0.05)。Survivin联合MUC7、Survivin、MUC7与尿脱落细胞细胞学的准确性分别是99.2%、95.5%、88.7%、81.2.3%,与脱落细胞学组比较,差异有统计学意义(P<0.05)。结论联合检测两种肿瘤标记物Survivin及MUC7可以提高膀胱癌诊断的敏感性和准确性。

Objective To investigate the clinical value of detection of Survivin and mucin 7 (MUC7) in urine in the diagnosis of bladder cancer. Methods Seventy-five patients with bladder cancer, 38 patients with benign diseases of urinary system and 20 healthy volunteers were enrolled, and three urine specimens were collected in all patients. The clinical value of three methods in the diagnosis of bladder cancer was analyzed and compared by detecting the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of Survivin, MUC7 and cytology in urine respectively. Results The sensitivity and specificity of Survivin in the diagnosis of bladder cancer were 93.3% and 98.3%, respectively. The sensitivity and specificity of MUC7 in the diagnosis of bladder cancer were 80% and 100%, respectively. The sensitivity and specificity of cytology in the diagnosis of bladder cancer were 66.7% and 100%, respectively. The sensitivity and specificity of Survivin combined with MUC7 were 98.7% and 100%, respectively. The significant differences were observed in the sensitivity when comparing Survivin or MUC7 with the cytology respectively (P<0.05). The accuracy of Survivin combined with MUC7, Survivin MUC7 and cytology were 99.2%, 95.5%, 88.7% and 81.2.3%, respectively, which had obviously increasement compared with cytology group (78.3%)(P<0.05, respectively). Conclusions Combination of Survivin and MUC7 can improve the sensitivity and accuracy in diagnosis of bladder cancer.