复方丹参滴丸联合激光光凝多点扫描治疗糖尿病视网膜病变的临床效果

Effects of Compound Danshen Dripping Pills Combined with Laser Photocoagulation on Diabetic Retinopathy

目的:探讨复方丹参滴丸联合激光光凝多点扫描治疗糖尿病视网膜病变的临床效果。方法:选取2014年1月至2016年1月解放军联勤保障部队第九四〇医院收治的2型糖尿病患者视网膜病变患者80例作为研究对象,按照随机数字表法分为观察组(n=43)和对照组(n=37)。所有患者均接受在治疗前,采用降血糖、降血压等内科治疗,观察组采取复方丹参滴丸联合激光光凝,对照组采用单纯激光光凝组治疗。观察2组治疗前后视力、血管瘤、黄斑厚度和30°内阈值敏感程度的变化;通过酶联免疫吸附试验(ELISA)检测血管内皮生长因子(VEGF)、白细胞介素-1β(IL-1β)、血管内皮细胞黏附分子1(VCAM-1)及核因子-κB(NF-κB)的变化。结果:治疗3个月后,观察组患者的视力、血管瘤、黄斑厚度、30°内阈值敏感程度明显改善;观察组患者血清VEGF、IL-1β、VCAM-1及NF-κB都低于对照组,差异有统计学意义(P <0. 05)。结论:复方丹参滴丸联合激光激光光凝扫描能够可有效改善视网膜组织的缺血缺氧状态,黄斑厚度、30°内阈值敏感度有效改善,提高患者生命质量。

Objective: To investigate the clinical effects of Compound Danshen Dripping Pills combined with laser photocoagulation on diabetic retinopathy. Methods: A total of 80 patients with type 2 diabetic retinopathy admitted in the 940th Hospital of Joint Logistics Support force of Chinese People′s Liberation Army from January 2014 to January 2016 were included as the research object,randomly divided into the treatment group( n =43)and the control group( n =37).All patients had received hypoglycemic,hypotensive and other internal medicine treatments before the study.The treatment group was treated with Compound Danshen Dripping Pills combined with laser photocoagulation,while the control group only received laser photocoagulation treatment.The changes in visual acuity,hemangioma,macular thickness and threshold sensitivity within 30 degrees in two groups of patients before and after treatment;tested the changes in the levels of vascular endothelial growth factor(VEGF),interleukin 1β(IL-1β),vascular endothelial cell adhesion 1(VCAM-1)and nuclear factor kappa B(NF-κB)were observed by enzyme-linked immune sorbent assay(ELISA). Results: After the treatment,the visual acuity,hemangioma,macular thickness,threshold sensitivity within 30 degrees of patients of the treatment group were significantly improved;the serum levels of VEGF,IL-1,VCAM-1 and NF-β Kappa B of patients in the treatment group were lower than those of the control group( P <0.05),whose difference was statistically significant. Conclusion: Compound Danshen Dripping Pills combined with laser photocoagulation can effectively improve the ischemia and hypoxia condition of the retinal tissue,as well as the threshold sensitivity within 30 degrees and the macular thickness,improve,and life quality of patients.