注射用红花黄色素对髋骨骨折患者下肢肿胀及生命质量的影响

Effects of Safflower Yellow Pigment for Injection on Lower Limb Swelling and Quality of Life in Patients with Hip Fracture

目的:探讨注射用红花黄色素对髋骨骨折患者下肢肿胀及生命质量的影响。方法:选取2013年3月至2017年3月芜湖市中医医院收治的髋骨骨折患者42例作为研究对象,随机分为对照组和观察组,每组21例。2组均行手术治疗,对照组术后给予常规西药,观察组在对照组治疗的基础上加用注射用红花黄色素,100 mg/次,1次/d。比较2组临床疗效;比较2组治疗前后下肢肿胀情况;评估治疗后2组髋关节与膝关节功能恢复状况;评估并比较2组生命质量。结果:观察组总有效率为85. 71%,显著组高于对照组的47. 62%(P <0. 05);与术后2 d比较,术后6 d、14 d 2组患者患肢肢体周径均显著缩小(P <0. 01),且观察组显著小于对照组(P <0. 05或P <0. 01);观察组患者下肢肿胀消失时间显著低于对照组(P <0. 01);治疗后观察组髋关节Harris评分中等级为优的患者比例高于对照组(P <0. 05);观察组患者主动直腿抬高时间、主动屈膝达90°时间显著短于对照组,膝关节主动活动度大于对照组(P <0. 05或P <0. 01);治疗后2组健康感觉、躯体感觉、精神状态、睡眠状态、生活满足感与食欲等评分均高于治疗前,且观察组以上评分均高于对照组(P <0. 01)。结论:注射用红花黄色素可显著改善髋骨骨折患者下肢肿胀状况,促进患者髋关节与膝关节功能的恢复,有效提升其生命质量,值得临床推广应用。

Objective: To explore the effects of safflower yellow pigment for injection on lower limb swelling and quality of life in patients with hip fracture. Methods: A total of 42 patients with hip fracture from March 2013 to March 2017 treated in Wuhu Hospital of Traditional Chinese Medicine were as the study objects,and were randomly divided into the observation group (21 cases) and the control group (21 cases).Both groups were treated by operation.The control group was given routine western medicine after operation,and the treatment group was treated with safflower yellow pigment for injection on the basis of the control group,and all were treated with 100 mg/time,once per day.The clinical effects in the 2 groups were compared;the lower limb swelling before and after treatment in the 2 groups was compared;the functional recovery of hip and knee joint in the 2 groups after treatment were evaluated;and the quality of life of the 2 groups were evaluated and compared. Results: The total effective rate of the treatment group was 85.71%,which was significantly higher than 47.62% in the control group ( P <0.05);Compared with 2 d after operation,the peripheral diameter of the affected limbs significantly reduced in the 2 groups 6 d,14 d day after operation ( P <0.01),and the observation group was significantly smaller than the control group ( P <0.05 or P <0.01);The time of disappearance of lower limb swelling in the observation group was significantly shorter than that in the control group ( P <0.01);The proportion of patients with excellent Harris score of hip joint in the observation group was significantly higher than that in the control group after treatment ( P <0.05);The time of active straight leg raising and 90 °flexion in the observation group was significantly shorter than that in the control group,and the active motion degree of the knee joint in the observation group was larger than that in the control group ( P <0.05 or P <0.01).After treatment,the scores of health sensation,somatosensory,mental state,sleep state,life satisfaction and appetite were significantly higher in the 2 groups than before treatment,and all the scores in the observation group were significantly higher than the control group ( P <0.01). Conclusion: Safflower yellow pigment for injection can significantly improve the swelling of lower extremity in patients with hip fracture,promote the recovery of coagulation function,and effectively improve the quality of life.It is worth popularizing and applying in clinic.